Abstract
A collagen-binding strain of Staphylococcus aureus produced suppurative inflammation in a rabbit model of soft contact lens-associated bacterial keratitis more often than its collagen-binding-negative isogenic mutant. Reintroduction of the cna gene on a multicopy plasmid into the mutant helped it regain its corneal adherence and infectivity. The topical application of a collagen-binding peptide before bacterial challenge decreased S. aureus adherence to deepithelialized corneas. These data suggest that the collagen- binding adhesin is involved in the pathogenesis of S. aureus infection of the cornea.
Original language | English (US) |
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Pages (from-to) | 3776-3779 |
Number of pages | 4 |
Journal | Infection and Immunity |
Volume | 68 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2000 |
ASJC Scopus subject areas
- Parasitology
- Microbiology
- Immunology
- Infectious Diseases