The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3

Hortensia Soto, Wei Wang, Robert M. Strieter, Neal G. Copeland, Debra J. Gilbert, Nancy A. Jenkins, Joseph Hedrick, Albert Zlotnik

Research output: Contribution to journalArticle

198 Scopus citations

Abstract

We cloned the mouse homologue of the chemokine receptor CXCR3, which is located in mouse chromosome X. We screened a large panel of chemokines for their ability to induce a calcium flux in mouse CXCR3-transfected cells and identified a new ligand for this receptor, the recently reported CC chemokine 6Ckine. This represents an example of a CC chemokine, which binds to a CXC chemokine receptor. Like other ligands of this receptor, 6Ckine has angiostatic properties. 6Ckine is known to chemoattract T cells. In line with this, CXCR3 is expressed preferentially in Th1 cells and in lymphoid organs of the IL-10(-/-) mouse that develops chronic colitis. Its ability to attract T cells as well as its angiostatic properties suggest that 6Ckine may be an effective anti-tumor agent.

Original languageEnglish (US)
Pages (from-to)8205-8210
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume95
Issue number14
DOIs
StatePublished - Jul 7 1998

ASJC Scopus subject areas

  • General

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