The Bladder Tumor Microenvironment

Hongbo Gao; Fotis Nikolos; Raj Satkunasivam; Keith Syson Chan

doi:10.1007/978-3-031-68505-7_12

The Bladder Tumor Microenvironment

Hongbo Gao, Fotis Nikolos, Raj Satkunasivam, Keith Syson Chan

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Current bladder cancer studies predominantly investigate tumor cell-intrinsic properties and tumor cell inherent mechanisms driving tumor development. The bladder tumor microenvironment, despite its significance, remains relatively understudied. It serves as a crucial tumor cell extrinsic factor, facilitating the malignant progression of cancer cells during tumor development. This chapter aims to provide an overview of current understanding and recent advances concerning the impact of the stromal cell compartment, associated extracellular matrix components, and the coexisting microbiome within the bladder tumor microenvironment on bladder cancer development.

Original language	English (US)
Title of host publication	Biology of Bladder Cancer
Subtitle of host publication	From Molecular Insights to Clinical Strategies
Publisher	Springer Nature
Pages	239-260
Number of pages	22
ISBN (Electronic)	9783031685057
ISBN (Print)	9783031685040
DOIs	https://doi.org/10.1007/978-3-031-68505-7_12
State	Published - Jan 1 2025

Keywords

Bladder stroma
Collagen
Discoidin domain receptor
Fibroblast heterogeneity
Stromal targeting
Tumor microenvironment

ASJC Scopus subject areas

General Medicine

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10.1007/978-3-031-68505-7_12

Cite this

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abstract = "Current bladder cancer studies predominantly investigate tumor cell-intrinsic properties and tumor cell inherent mechanisms driving tumor development. The bladder tumor microenvironment, despite its significance, remains relatively understudied. It serves as a crucial tumor cell extrinsic factor, facilitating the malignant progression of cancer cells during tumor development. This chapter aims to provide an overview of current understanding and recent advances concerning the impact of the stromal cell compartment, associated extracellular matrix components, and the coexisting microbiome within the bladder tumor microenvironment on bladder cancer development.",

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AU - Gao, Hongbo

AU - Nikolos, Fotis

AU - Satkunasivam, Raj

AU - Chan, Keith Syson

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Y1 - 2025/1/1

N2 - Current bladder cancer studies predominantly investigate tumor cell-intrinsic properties and tumor cell inherent mechanisms driving tumor development. The bladder tumor microenvironment, despite its significance, remains relatively understudied. It serves as a crucial tumor cell extrinsic factor, facilitating the malignant progression of cancer cells during tumor development. This chapter aims to provide an overview of current understanding and recent advances concerning the impact of the stromal cell compartment, associated extracellular matrix components, and the coexisting microbiome within the bladder tumor microenvironment on bladder cancer development.

AB - Current bladder cancer studies predominantly investigate tumor cell-intrinsic properties and tumor cell inherent mechanisms driving tumor development. The bladder tumor microenvironment, despite its significance, remains relatively understudied. It serves as a crucial tumor cell extrinsic factor, facilitating the malignant progression of cancer cells during tumor development. This chapter aims to provide an overview of current understanding and recent advances concerning the impact of the stromal cell compartment, associated extracellular matrix components, and the coexisting microbiome within the bladder tumor microenvironment on bladder cancer development.

KW - Bladder stroma

KW - Collagen

KW - Discoidin domain receptor

KW - Fibroblast heterogeneity

KW - Stromal targeting

KW - Tumor microenvironment

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PB - Springer Nature

ER -

The Bladder Tumor Microenvironment

Abstract

Keywords

ASJC Scopus subject areas

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