The B Cell Response to Transplantation Antigens

Roger Sciammas, Anita S. Chong, Robert B. Colvin

Research output: Chapter in Book/Report/Conference proceedingChapter


Transplantation, historically attributed to be T cell driven, is experiencing a revision regarding the criticality of B cells. This reconsideration has evolved in part from the unexpected benefits of preventing allograft rejection by specific targeting of B cells. These functional observations, coupled with strong correlations between incidence of graft dysfunction and the presence of high titers of donor-specific antibody and complement C4d deposition in the allograft, suggest that controlling B cell activity during transplantation may be necessary to improving our current immunosuppression protocols. In this review, we describe the fundamental features of B cell biology and discuss how they pertain to transplantation.

Original languageEnglish (US)
Title of host publicationImmunotherapy in Transplantation
Subtitle of host publicationPrinciples and Practice
Number of pages16
ISBN (Print)9781405182713
StatePublished - Apr 19 2012


  • Antibody
  • B cell
  • Complement
  • Plasma cell
  • Rejection

ASJC Scopus subject areas

  • Medicine(all)


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