The autoimmune T and B cell repertoires in monozygotic twins discordant for myasthenia gravis

M. Kakoulidou, R. Åhlberg, Qing Yi, R. Giscombe, R. Pirskanen, A. K. Lefvert

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Two pairs of monozygotic twins, discordant for myasthenia gravis (MG) for more than 30 years, were studied regarding T cell and antibody reactivity against disease related autoantigens, the acetylcholine receptor, one idiotypic and one anti-idiotypic human monoclonal antibody. The healthy and myasthenic twins had very similar autoantibody repertoires. IgG fractions from both healthy and myasthenic twins had the same capacity to decrease the free acetylcholine receptor content in mice after passive transfer. In comparison with their myasthenic sisters, the healthy twins had lower T cell responses against the acetylcholine receptor.

Original languageEnglish (US)
Pages (from-to)183-191
Number of pages9
JournalJournal of Neuroimmunology
Volume148
Issue number1-2
DOIs
StatePublished - Jan 1 2004

Keywords

  • Auto antibodies
  • B-lymphocyte
  • Myasthenia gravis
  • T lymphocyte
  • Twin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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