The autoimmune T and B cell repertoires in monozygotic twins discordant for myasthenia gravis

M. Kakoulidou; R. Åhlberg; Q. Yi; R. Giscombe; R. Pirskanen; A. K. Lefvert

doi:10.1016/j.jneuroim.2003.09.019

The autoimmune T and B cell repertoires in monozygotic twins discordant for myasthenia gravis

M. Kakoulidou, R. Åhlberg, Q. Yi, R. Giscombe, R. Pirskanen, A. K. Lefvert

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Two pairs of monozygotic twins, discordant for myasthenia gravis (MG) for more than 30 years, were studied regarding T cell and antibody reactivity against disease related autoantigens, the acetylcholine receptor, one idiotypic and one anti-idiotypic human monoclonal antibody. The healthy and myasthenic twins had very similar autoantibody repertoires. IgG fractions from both healthy and myasthenic twins had the same capacity to decrease the free acetylcholine receptor content in mice after passive transfer. In comparison with their myasthenic sisters, the healthy twins had lower T cell responses against the acetylcholine receptor.

Original language	English (US)
Pages (from-to)	183-191
Number of pages	9
Journal	Journal of Neuroimmunology
Volume	148
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2003.09.019
State	Published - Mar 2004

Keywords

Auto antibodies
B-lymphocyte
Myasthenia gravis
T lymphocyte
Twin

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2003.09.019

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title = "The autoimmune T and B cell repertoires in monozygotic twins discordant for myasthenia gravis",

abstract = "Two pairs of monozygotic twins, discordant for myasthenia gravis (MG) for more than 30 years, were studied regarding T cell and antibody reactivity against disease related autoantigens, the acetylcholine receptor, one idiotypic and one anti-idiotypic human monoclonal antibody. The healthy and myasthenic twins had very similar autoantibody repertoires. IgG fractions from both healthy and myasthenic twins had the same capacity to decrease the free acetylcholine receptor content in mice after passive transfer. In comparison with their myasthenic sisters, the healthy twins had lower T cell responses against the acetylcholine receptor.",

keywords = "Auto antibodies, B-lymphocyte, Myasthenia gravis, T lymphocyte, Twin",

author = "M. Kakoulidou and R. {\AA}hlberg and Q. Yi and R. Giscombe and R. Pirskanen and Lefvert, {A. K.}",

note = "Funding Information: This study was supported by grants from the European Commission, the Fifth Framework Programme, the Swedish Research Council, the foundations of the Karolinska Institutet and the Palle Ferb foundation. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

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doi = "10.1016/j.jneuroim.2003.09.019",

language = "English (US)",

volume = "148",

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AU - Kakoulidou, M.

AU - Åhlberg, R.

AU - Yi, Q.

AU - Giscombe, R.

AU - Pirskanen, R.

AU - Lefvert, A. K.

N1 - Funding Information: This study was supported by grants from the European Commission, the Fifth Framework Programme, the Swedish Research Council, the foundations of the Karolinska Institutet and the Palle Ferb foundation. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2004/3

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N2 - Two pairs of monozygotic twins, discordant for myasthenia gravis (MG) for more than 30 years, were studied regarding T cell and antibody reactivity against disease related autoantigens, the acetylcholine receptor, one idiotypic and one anti-idiotypic human monoclonal antibody. The healthy and myasthenic twins had very similar autoantibody repertoires. IgG fractions from both healthy and myasthenic twins had the same capacity to decrease the free acetylcholine receptor content in mice after passive transfer. In comparison with their myasthenic sisters, the healthy twins had lower T cell responses against the acetylcholine receptor.

AB - Two pairs of monozygotic twins, discordant for myasthenia gravis (MG) for more than 30 years, were studied regarding T cell and antibody reactivity against disease related autoantigens, the acetylcholine receptor, one idiotypic and one anti-idiotypic human monoclonal antibody. The healthy and myasthenic twins had very similar autoantibody repertoires. IgG fractions from both healthy and myasthenic twins had the same capacity to decrease the free acetylcholine receptor content in mice after passive transfer. In comparison with their myasthenic sisters, the healthy twins had lower T cell responses against the acetylcholine receptor.

KW - Auto antibodies

KW - B-lymphocyte

KW - Myasthenia gravis

KW - T lymphocyte

KW - Twin

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The autoimmune T and B cell repertoires in monozygotic twins discordant for myasthenia gravis

Abstract

Keywords

ASJC Scopus subject areas

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