The aryl hydrocarbon (Ah) receptor has been widely identified in mammalian tissues, and the molecular properties of this protein have been characterized. Extensive research on the molecular biology of the induction of cytochrome P-4501A1 by toxic halogenated aryl hydrocarbons, typified by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and carcinogenic polynuclear aromatic hydrocarbons, typified by 3-methylcholanthrene (MC), clearly confirms the role of the occupied Ah receptor-ligand complex in this induction process. In contrast, the molecular mechanisms associated with other Ah receptor-mediated toxic and genotoxic responses to TCDD, MC, and related compounds are less well understood, and the unraveling of these mechanisms remains as a major challenge for future research.
|Original language||English (US)|
|Number of pages||6|
|Journal||ISI Atlas of Science: Pharmacology|
|State||Published - 1988|
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)