The Artificial Urinary Sphincter Improves Emotional Health in Men With Stress Urinary Incontinence: Results From the Prospective, Multi-institutional AUSCO Study

Andrew C. Peterson; Hadley M. Wood; Jeremy Myers; Benjamin N. Breyer; Bradley A. Erickson; Thomas G. Smith; Erin L. Chaussee; Melissa R. Kaufman; Ryan Terlecki; Niels V. Johnsen; Alex J. Vanni; Daniel Moon; Le Roy Jones; Joshua A. Broghammer; Gerard Henry; Arthur L. Burnett; Lewis Wen Loong Chan; Brian J. Flynn; Rose Khavari; Sean Elliott

doi:10.1016/j.urology.2025.09.037

The Artificial Urinary Sphincter Improves Emotional Health in Men With Stress Urinary Incontinence: Results From the Prospective, Multi-institutional AUSCO Study

Andrew C. Peterson, Hadley M. Wood, Jeremy Myers, Benjamin N. Breyer, Bradley A. Erickson, Thomas G. Smith, Erin L. Chaussee, Melissa R. Kaufman, Ryan Terlecki, Niels V. Johnsen, Alex J. Vanni, Daniel Moon, Le Roy Jones, Joshua A. Broghammer, Gerard Henry, Arthur L. Burnett, Lewis Wen Loong Chan, Brian J. Flynn, Rose Khavari, Sean Elliott

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: To examine the effects on depression, anxiety, and overall emotional health in patients undergoing artificial urinary sphincter (AUS) surgery for stress urinary incontinence (SUI). Few reports focus on the impact of AUS implantation on emotional health in men with SUI.

METHODS: The AUS Clinical Outcomes Trial (AUSCO) was a prospective, single-arm, multi-site study designed to evaluate outcomes in men with SUI treated with the AMS 800 AUS (NCT04088331). A total of 115 subjects were implanted. Follow-up assessments at 3-, 6-, and 12-months post device activation were compared to baseline. These analyses focus on emotional health, measured with the Incontinence QOL (I-QOL), Incontinence Impact Questionnaire (IIQ-7), and EQ-5D-5L.

RESULTS: At 12 months, 100 had completed QOL assessments. Depression rating (Item 5, I-QOL) significantly improved, with 85% (85/100) of patients reporting feeling at least "a little" depressed at baseline decreasing to 39% (39/100) at 12 months (p<0.0001). Emotional health rating (Item 6, IIQ-7) also improved, with 16% (16/100) reporting being "greatly" affected by incontinence at baseline decreasing to 3% (3/100) at 12 months (P <.0001). The anxiety/depression domain on the EQ-5D-5L (Item 5) was also significantly improved, with 50% (50/100) of patients reporting being at least "slightly" anxious or depressed at baseline decreasing to 30% (30/100) at 12 months (P =<0.0001).

CONCLUSION: These data demonstrate that treatment of SUI with the AUS improves emotional health in men with SUI.

Original language	English (US)
Pages (from-to)	227-232
Number of pages	6
Journal	Urology
Volume	207
DOIs	https://doi.org/10.1016/j.urology.2025.09.037
State	Published - Jan 2026

Keywords

Prospective Studies
Anxiety/etiology
Humans
Middle Aged
Male
Treatment Outcome
Urinary Incontinence, Stress/surgery
Mental Health
Emotions
Quality of Life
Aged
Depression/etiology
Urinary Sphincter, Artificial

ASJC Scopus subject areas

Urology

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10.1016/j.urology.2025.09.037

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Peterson, A. C., Wood, H. M., Myers, J., Breyer, B. N., Erickson, B. A., Smith, T. G., Chaussee, E. L., Kaufman, M. R., Terlecki, R., Johnsen, N. V., Vanni, A. J., Moon, D., Jones, L. R., Broghammer, J. A., Henry, G., Burnett, A. L., Chan, L. W. L., Flynn, B. J., Khavari, R., & Elliott, S. (2026). The Artificial Urinary Sphincter Improves Emotional Health in Men With Stress Urinary Incontinence: Results From the Prospective, Multi-institutional AUSCO Study. Urology, 207, 227-232. https://doi.org/10.1016/j.urology.2025.09.037

Peterson, AC, Wood, HM, Myers, J, Breyer, BN, Erickson, BA, Smith, TG, Chaussee, EL, Kaufman, MR, Terlecki, R, Johnsen, NV, Vanni, AJ, Moon, D, Jones, LR, Broghammer, JA, Henry, G, Burnett, AL, Chan, LWL, Flynn, BJ, Khavari, R & Elliott, S 2026, 'The Artificial Urinary Sphincter Improves Emotional Health in Men With Stress Urinary Incontinence: Results From the Prospective, Multi-institutional AUSCO Study', Urology, vol. 207, pp. 227-232. https://doi.org/10.1016/j.urology.2025.09.037

@article{d5ad3044e22347dbba483fe9645065dd,

title = "The Artificial Urinary Sphincter Improves Emotional Health in Men With Stress Urinary Incontinence: Results From the Prospective, Multi-institutional AUSCO Study",

abstract = "OBJECTIVE: To examine the effects on depression, anxiety, and overall emotional health in patients undergoing artificial urinary sphincter (AUS) surgery for stress urinary incontinence (SUI). Few reports focus on the impact of AUS implantation on emotional health in men with SUI.METHODS: The AUS Clinical Outcomes Trial (AUSCO) was a prospective, single-arm, multi-site study designed to evaluate outcomes in men with SUI treated with the AMS 800 AUS (NCT04088331). A total of 115 subjects were implanted. Follow-up assessments at 3-, 6-, and 12-months post device activation were compared to baseline. These analyses focus on emotional health, measured with the Incontinence QOL (I-QOL), Incontinence Impact Questionnaire (IIQ-7), and EQ-5D-5L.RESULTS: At 12 months, 100 had completed QOL assessments. Depression rating (Item 5, I-QOL) significantly improved, with 85\% (85/100) of patients reporting feeling at least {"}a little{"} depressed at baseline decreasing to 39\% (39/100) at 12 months (p<0.0001). Emotional health rating (Item 6, IIQ-7) also improved, with 16\% (16/100) reporting being {"}greatly{"} affected by incontinence at baseline decreasing to 3\% (3/100) at 12 months (P <.0001). The anxiety/depression domain on the EQ-5D-5L (Item 5) was also significantly improved, with 50\% (50/100) of patients reporting being at least {"}slightly{"} anxious or depressed at baseline decreasing to 30\% (30/100) at 12 months (P =<0.0001).CONCLUSION: These data demonstrate that treatment of SUI with the AUS improves emotional health in men with SUI.",

keywords = "Prospective Studies, Anxiety/etiology, Humans, Middle Aged, Male, Treatment Outcome, Urinary Incontinence, Stress/surgery, Mental Health, Emotions, Quality of Life, Aged, Depression/etiology, Urinary Sphincter, Artificial",

author = "Peterson, \{Andrew C.\} and Wood, \{Hadley M.\} and Jeremy Myers and Breyer, \{Benjamin N.\} and Erickson, \{Bradley A.\} and Smith, \{Thomas G.\} and Chaussee, \{Erin L.\} and Kaufman, \{Melissa R.\} and Ryan Terlecki and Johnsen, \{Niels V.\} and Vanni, \{Alex J.\} and Daniel Moon and Jones, \{Le Roy\} and Broghammer, \{Joshua A.\} and Gerard Henry and Burnett, \{Arthur L.\} and Chan, \{Lewis Wen Loong\} and Flynn, \{Brian J.\} and Rose Khavari and Sean Elliott",

note = "Publisher Copyright: {\textcopyright} 2025 The Authors.",

year = "2026",

month = jan,

doi = "10.1016/j.urology.2025.09.037",

language = "English (US)",

volume = "207",

pages = "227--232",

journal = "Urology",

issn = "0090-4295",

publisher = "Elsevier",

}

TY - JOUR

T1 - The Artificial Urinary Sphincter Improves Emotional Health in Men With Stress Urinary Incontinence

T2 - Results From the Prospective, Multi-institutional AUSCO Study

AU - Peterson, Andrew C.

AU - Wood, Hadley M.

AU - Myers, Jeremy

AU - Breyer, Benjamin N.

AU - Erickson, Bradley A.

AU - Smith, Thomas G.

AU - Chaussee, Erin L.

AU - Kaufman, Melissa R.

AU - Terlecki, Ryan

AU - Johnsen, Niels V.

AU - Vanni, Alex J.

AU - Moon, Daniel

AU - Jones, Le Roy

AU - Broghammer, Joshua A.

AU - Henry, Gerard

AU - Burnett, Arthur L.

AU - Chan, Lewis Wen Loong

AU - Flynn, Brian J.

AU - Khavari, Rose

AU - Elliott, Sean

PY - 2026/1

Y1 - 2026/1

N2 - OBJECTIVE: To examine the effects on depression, anxiety, and overall emotional health in patients undergoing artificial urinary sphincter (AUS) surgery for stress urinary incontinence (SUI). Few reports focus on the impact of AUS implantation on emotional health in men with SUI.METHODS: The AUS Clinical Outcomes Trial (AUSCO) was a prospective, single-arm, multi-site study designed to evaluate outcomes in men with SUI treated with the AMS 800 AUS (NCT04088331). A total of 115 subjects were implanted. Follow-up assessments at 3-, 6-, and 12-months post device activation were compared to baseline. These analyses focus on emotional health, measured with the Incontinence QOL (I-QOL), Incontinence Impact Questionnaire (IIQ-7), and EQ-5D-5L.RESULTS: At 12 months, 100 had completed QOL assessments. Depression rating (Item 5, I-QOL) significantly improved, with 85% (85/100) of patients reporting feeling at least "a little" depressed at baseline decreasing to 39% (39/100) at 12 months (p<0.0001). Emotional health rating (Item 6, IIQ-7) also improved, with 16% (16/100) reporting being "greatly" affected by incontinence at baseline decreasing to 3% (3/100) at 12 months (P <.0001). The anxiety/depression domain on the EQ-5D-5L (Item 5) was also significantly improved, with 50% (50/100) of patients reporting being at least "slightly" anxious or depressed at baseline decreasing to 30% (30/100) at 12 months (P =<0.0001).CONCLUSION: These data demonstrate that treatment of SUI with the AUS improves emotional health in men with SUI.

AB - OBJECTIVE: To examine the effects on depression, anxiety, and overall emotional health in patients undergoing artificial urinary sphincter (AUS) surgery for stress urinary incontinence (SUI). Few reports focus on the impact of AUS implantation on emotional health in men with SUI.METHODS: The AUS Clinical Outcomes Trial (AUSCO) was a prospective, single-arm, multi-site study designed to evaluate outcomes in men with SUI treated with the AMS 800 AUS (NCT04088331). A total of 115 subjects were implanted. Follow-up assessments at 3-, 6-, and 12-months post device activation were compared to baseline. These analyses focus on emotional health, measured with the Incontinence QOL (I-QOL), Incontinence Impact Questionnaire (IIQ-7), and EQ-5D-5L.RESULTS: At 12 months, 100 had completed QOL assessments. Depression rating (Item 5, I-QOL) significantly improved, with 85% (85/100) of patients reporting feeling at least "a little" depressed at baseline decreasing to 39% (39/100) at 12 months (p<0.0001). Emotional health rating (Item 6, IIQ-7) also improved, with 16% (16/100) reporting being "greatly" affected by incontinence at baseline decreasing to 3% (3/100) at 12 months (P <.0001). The anxiety/depression domain on the EQ-5D-5L (Item 5) was also significantly improved, with 50% (50/100) of patients reporting being at least "slightly" anxious or depressed at baseline decreasing to 30% (30/100) at 12 months (P =<0.0001).CONCLUSION: These data demonstrate that treatment of SUI with the AUS improves emotional health in men with SUI.

KW - Prospective Studies

KW - Anxiety/etiology

KW - Humans

KW - Middle Aged

KW - Male

KW - Treatment Outcome

KW - Urinary Incontinence, Stress/surgery

KW - Mental Health

KW - Emotions

KW - Quality of Life

KW - Aged

KW - Depression/etiology

KW - Urinary Sphincter, Artificial

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UR - https://www.scopus.com/inward/citedby.url?scp=105024958348&partnerID=8YFLogxK

U2 - 10.1016/j.urology.2025.09.037

DO - 10.1016/j.urology.2025.09.037

M3 - Article

C2 - 41043618

AN - SCOPUS:105024958348

SN - 0090-4295

VL - 207

SP - 227

EP - 232

JO - Urology

JF - Urology

ER -

The Artificial Urinary Sphincter Improves Emotional Health in Men With Stress Urinary Incontinence: Results From the Prospective, Multi-institutional AUSCO Study

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Keywords

ASJC Scopus subject areas

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