TY - JOUR
T1 - The analysis of portal vein thrombosis following orthotopic liver transplantation
AU - You, Shen
AU - He, Xiao Shun
AU - Hu, An Bin
AU - Xiong, Jun
AU - Wu, Lin Wei
AU - Wang, Dong Ping
AU - Wang, Guo Dong
AU - Ma, Y.
AU - Ju, Wei Qiang
AU - Huang, Jie Fu
N1 - Copyright:
This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
PY - 2008/2/1
Y1 - 2008/2/1
N2 - OBJECTIVE: To investigate and summarize the experience in clinical presentation, diagnosis and treatment of portal vein thrombosis after orthotopic liver transplantation (OLT). METHODS: The clinical data of 402 patients who underwent OLT from January 2003 to February 2007 were reviewed. A retrospective study was performed on etiology, prognosis and treatment in 9 cases of portal vein thrombosis after OLT. RESULTS: All of the 9 cases received anticoagulant and antiaggregation therapy, within whom one underwent percutaneous transluminal angioplasty and stent placement, one underwent retransplantation after failure of thrombolysis therapy, and one received surgical embolectomy. Six patients died of multiple organ failure on 9th, 30th, 34th, 40th, 48th, 6 2nd days, respectively, while 3 patients survived. CONCLUSIONS: The major risk factors of portal vein thrombosis after OLT were pathological changes in portal vein, abnormal blood stream dynamics, hypercoagulable status and improper surgical technique. Prophylactic intervention to patients with high risk factors, early diagnosis and aggressive comprehensive therapy on portal vein thrombosis patients are essential to improve prognosis.
AB - OBJECTIVE: To investigate and summarize the experience in clinical presentation, diagnosis and treatment of portal vein thrombosis after orthotopic liver transplantation (OLT). METHODS: The clinical data of 402 patients who underwent OLT from January 2003 to February 2007 were reviewed. A retrospective study was performed on etiology, prognosis and treatment in 9 cases of portal vein thrombosis after OLT. RESULTS: All of the 9 cases received anticoagulant and antiaggregation therapy, within whom one underwent percutaneous transluminal angioplasty and stent placement, one underwent retransplantation after failure of thrombolysis therapy, and one received surgical embolectomy. Six patients died of multiple organ failure on 9th, 30th, 34th, 40th, 48th, 6 2nd days, respectively, while 3 patients survived. CONCLUSIONS: The major risk factors of portal vein thrombosis after OLT were pathological changes in portal vein, abnormal blood stream dynamics, hypercoagulable status and improper surgical technique. Prophylactic intervention to patients with high risk factors, early diagnosis and aggressive comprehensive therapy on portal vein thrombosis patients are essential to improve prognosis.
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M3 - Article
C2 - 18683711
AN - SCOPUS:64049108205
VL - 46
SP - 176
EP - 178
JO - Zhonghua wai ke za zhi [Chinese journal of surgery]
JF - Zhonghua wai ke za zhi [Chinese journal of surgery]
SN - 0529-5815
IS - 3
ER -