The air pollutant 2-nitrofluorene as initiator and promoter in a liver model for chemical carcinogenesis

L. Möller; U. B. Torndal; L. C. Eriksson; J. Å Gustafsson

doi:10.1093/carcin/10.3.435

The air pollutant 2-nitrofluorene as initiator and promoter in a liver model for chemical carcinogenesis

L. Möller, U. B. Torndal, L. C. Eriksson, J. Å Gustafsson

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Abstract

2-Nitrofluorene (NF), a model substance for nitrated polycyclic aromatic hydrocarbons, is present in exhaust from diesel- and petrol-driven vehicles, in exhaust from kerosene heaters, and in urban air and river sediments. Therefore the possible consequences of human exposure are important to elucidate. In the present study the initiating and promoting activity of NF was studied in a liver model for chemical carcinogenesis in the rat. Furthermore, the in vivo metabolism and formation of genotoxic metabolites of NF were investigated. NF was found to be a moderate initiator and a weak promoter when compared to diethylnitrosamine (DEN) and 2-acetylamino-fluorene (AAF) respectively, both of which are potent carcinogens. Animals given NF excreted more urinary mutagenicity when compared to animals given AAF or DEN.

Original language	English (US)
Pages (from-to)	435-440
Number of pages	6
Journal	Carcinogenesis
Volume	10
Issue number	3
DOIs	https://doi.org/10.1093/carcin/10.3.435
State	Published - Mar 1989

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Cancer Research

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title = "The air pollutant 2-nitrofluorene as initiator and promoter in a liver model for chemical carcinogenesis",

abstract = "2-Nitrofluorene (NF), a model substance for nitrated polycyclic aromatic hydrocarbons, is present in exhaust from diesel- and petrol-driven vehicles, in exhaust from kerosene heaters, and in urban air and river sediments. Therefore the possible consequences of human exposure are important to elucidate. In the present study the initiating and promoting activity of NF was studied in a liver model for chemical carcinogenesis in the rat. Furthermore, the in vivo metabolism and formation of genotoxic metabolites of NF were investigated. NF was found to be a moderate initiator and a weak promoter when compared to diethylnitrosamine (DEN) and 2-acetylamino-fluorene (AAF) respectively, both of which are potent carcinogens. Animals given NF excreted more urinary mutagenicity when compared to animals given AAF or DEN.",

author = "L. M{\"o}ller and Torndal, {U. B.} and Eriksson, {L. C.} and Gustafsson, {J. {\AA}}",

note = "Funding Information: We wish to thank Dr Joseph Rafter for helpful discussions regarding the manuscript and Christina Thulin and Ingegerd Muhonen for excellent technical assistance. This project was supported by the National Swedish Environmental Protection Board, the Swedish Medical Research Council, the Swedish Cancer Society and the US National Cancer Institute (grant 1RO1 CA 42054-01). Copyright: Copyright 2010 Elsevier B.V., All rights reserved.",

year = "1989",

month = mar,

doi = "10.1093/carcin/10.3.435",

language = "English (US)",

volume = "10",

pages = "435--440",

journal = "Carcinogenesis",

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T1 - The air pollutant 2-nitrofluorene as initiator and promoter in a liver model for chemical carcinogenesis

AU - Möller, L.

AU - Torndal, U. B.

AU - Eriksson, L. C.

AU - Gustafsson, J. Å

N1 - Funding Information: We wish to thank Dr Joseph Rafter for helpful discussions regarding the manuscript and Christina Thulin and Ingegerd Muhonen for excellent technical assistance. This project was supported by the National Swedish Environmental Protection Board, the Swedish Medical Research Council, the Swedish Cancer Society and the US National Cancer Institute (grant 1RO1 CA 42054-01). Copyright: Copyright 2010 Elsevier B.V., All rights reserved.

PY - 1989/3

Y1 - 1989/3

N2 - 2-Nitrofluorene (NF), a model substance for nitrated polycyclic aromatic hydrocarbons, is present in exhaust from diesel- and petrol-driven vehicles, in exhaust from kerosene heaters, and in urban air and river sediments. Therefore the possible consequences of human exposure are important to elucidate. In the present study the initiating and promoting activity of NF was studied in a liver model for chemical carcinogenesis in the rat. Furthermore, the in vivo metabolism and formation of genotoxic metabolites of NF were investigated. NF was found to be a moderate initiator and a weak promoter when compared to diethylnitrosamine (DEN) and 2-acetylamino-fluorene (AAF) respectively, both of which are potent carcinogens. Animals given NF excreted more urinary mutagenicity when compared to animals given AAF or DEN.

AB - 2-Nitrofluorene (NF), a model substance for nitrated polycyclic aromatic hydrocarbons, is present in exhaust from diesel- and petrol-driven vehicles, in exhaust from kerosene heaters, and in urban air and river sediments. Therefore the possible consequences of human exposure are important to elucidate. In the present study the initiating and promoting activity of NF was studied in a liver model for chemical carcinogenesis in the rat. Furthermore, the in vivo metabolism and formation of genotoxic metabolites of NF were investigated. NF was found to be a moderate initiator and a weak promoter when compared to diethylnitrosamine (DEN) and 2-acetylamino-fluorene (AAF) respectively, both of which are potent carcinogens. Animals given NF excreted more urinary mutagenicity when compared to animals given AAF or DEN.

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The air pollutant 2-nitrofluorene as initiator and promoter in a liver model for chemical carcinogenesis

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