The air pollutant 2-nitrofluorene as initiator and promoter in a liver model for chemical carcinogenesis

L. Möller, U. B. Torndal, L. C. Eriksson, J. Å Gustafsson

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

2-Nitrofluorene (NF), a model substance for nitrated polycyclic aromatic hydrocarbons, is present in exhaust from diesel- and petrol-driven vehicles, in exhaust from kerosene heaters, and in urban air and river sediments. Therefore the possible consequences of human exposure are important to elucidate. In the present study the initiating and promoting activity of NF was studied in a liver model for chemical carcinogenesis in the rat. Furthermore, the in vivo metabolism and formation of genotoxic metabolites of NF were investigated. NF was found to be a moderate initiator and a weak promoter when compared to diethylnitrosamine (DEN) and 2-acetylamino-fluorene (AAF) respectively, both of which are potent carcinogens. Animals given NF excreted more urinary mutagenicity when compared to animals given AAF or DEN.

Original languageEnglish (US)
Pages (from-to)435-440
Number of pages6
JournalCarcinogenesis
Volume10
Issue number3
DOIs
StatePublished - Mar 1989

ASJC Scopus subject areas

  • Cancer Research

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