The 2-year leakage index and quantitative microaneurysm results of the RECOVERY study: Quantitative ultra-widefield findings in proliferative diabetic retinopathy treated with intravitreal aflibercept

Amy S. Babiuch, Charles C. Wykoff, Sari Yordi, Hannah Yu, Sunil K. Srivastava, Ming Hu, Thuy K. Le, Leina Lunasco, Jamie Reese, Muneeswar G. Nittala, Srinivas R. Sadda, Justis P. Ehlers

Research output: Contribution to journalArticlepeer-review

Abstract

Eyes with proliferative diabetic retinopathy (PDR) have been shown to improve in the leakage index and microaneurysm (MA) count after intravitreal aflibercept (IAI) treatment. The authors investigated these changes via automatic segmentation on ultra-widefield fluorescein angiography (UWFA). Forty subjects with PDR were randomized to receive either 2 mg IAI every 4 weeks (Arm 1) or every 12 weeks (Arm 2) through Year 1. After Year 1, Arm 1 switched to quarterly IAI and Arm 2 to monthly IAI through Year 2. By Year 2, the Arm 1 leakage index decreased by 43% from Baseline (p = 0.03) but increased by 59% from Year 1 (p = 0.04). Arm 2 decreased by 61% from Baseline (p = 0.008) and by 31% from Year 1 (p = 0.12). Both cohorts exhibited a significant decline in MAs from Baseline to Year 2 (871 to 410; p < 0.001; 776 to 207; p < 0.001, respectively). Subjects with an improved leakage and MA count showed a more significant improvement in the Diabetic Retinopathy Severity Scale (DRSS) score. Moreover, central subfield thickness (CST) was positively associated with changes in the leakage index. In conclusion, the leakage index and MA counts significantly improved from Baseline following IAI treatment, and monthly injections provided a more rapid and sustained reduction in these parameters compared with quarterly injections.

Original languageEnglish (US)
Article number1126
JournalJournal of Personalized Medicine
Volume11
Issue number11
DOIs
StatePublished - Nov 2021

Keywords

  • Anti-vascular endothelial growth factor
  • Diabetic macular edema
  • Diabetic retinopathy
  • Intravitreal aflibercept
  • Leakage index
  • Microaneurysms
  • Neovascularization
  • Optical coherence tomography
  • Ultra-widefield fluorescein angiography

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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