Th1-specific bystander costimulation imparts resistance against Mycobacterium tuberculosis infection

G. Das; H. Vohra; B. Saha; G. C. Mishra

doi:10.1046/j.1365-3083.2000.00808.x

Th1-specific bystander costimulation imparts resistance against Mycobacterium tuberculosis infection

G. Das, H. Vohra, B. Saha, G. C. Mishra

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The protection against Mycobacterium tuberculosis infection is mediated by T helper type-1 (Th1) cells. Infection of BALB/c mice with M. tuberculosis downregulates expression of a Th1-specific costimulatory molecule, M150, on the surface of infected macrophages. The proliferation of Th cells and Th1-cytokine production by these cells are higher in case of M. tuberculosis antigen presentation by uninfected macrophages than by infected macrophages. The difference in inducing interleukin(IL)-2 and interferon (IFN)-γ secretion is abolished by providing bystander costimulation through M150 on liposomes.

Original language	English (US)
Pages (from-to)	515-518
Number of pages	4
Journal	Scandinavian Journal of Immunology
Volume	52
Issue number	5
DOIs	https://doi.org/10.1046/j.1365-3083.2000.00808.x
State	Published - 2000

ASJC Scopus subject areas

Immunology

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10.1046/j.1365-3083.2000.00808.x

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abstract = "The protection against Mycobacterium tuberculosis infection is mediated by T helper type-1 (Th1) cells. Infection of BALB/c mice with M. tuberculosis downregulates expression of a Th1-specific costimulatory molecule, M150, on the surface of infected macrophages. The proliferation of Th cells and Th1-cytokine production by these cells are higher in case of M. tuberculosis antigen presentation by uninfected macrophages than by infected macrophages. The difference in inducing interleukin(IL)-2 and interferon (IFN)-γ secretion is abolished by providing bystander costimulation through M150 on liposomes.",

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AU - Saha, B.

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Y1 - 2000

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AB - The protection against Mycobacterium tuberculosis infection is mediated by T helper type-1 (Th1) cells. Infection of BALB/c mice with M. tuberculosis downregulates expression of a Th1-specific costimulatory molecule, M150, on the surface of infected macrophages. The proliferation of Th cells and Th1-cytokine production by these cells are higher in case of M. tuberculosis antigen presentation by uninfected macrophages than by infected macrophages. The difference in inducing interleukin(IL)-2 and interferon (IFN)-γ secretion is abolished by providing bystander costimulation through M150 on liposomes.

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Th1-specific bystander costimulation imparts resistance against Mycobacterium tuberculosis infection

Abstract

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