Th1-specific bystander costimulation imparts resistance against Mycobacterium tuberculosis infection

Gobardhan Das, H. Vohra, B. Saha, G. C. Mishra

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The protection against Mycobacterium tuberculosis infection is mediated by T helper type-1 (Th1) cells. Infection of BALB/c mice with M. tuberculosis downregulates expression of a Th1-specific costimulatory molecule, M150, on the surface of infected macrophages. The proliferation of Th cells and Th1-cytokine production by these cells are higher in case of M. tuberculosis antigen presentation by uninfected macrophages than by infected macrophages. The difference in inducing interleukin(IL)-2 and interferon (IFN)-γ secretion is abolished by providing bystander costimulation through M150 on liposomes.

Original languageEnglish (US)
Pages (from-to)515-518
Number of pages4
JournalScandinavian Journal of Immunology
Volume52
Issue number5
DOIs
StatePublished - Dec 16 2000

ASJC Scopus subject areas

  • Immunology

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