TY - JOUR
T1 - Th1-specific bystander costimulation imparts resistance against Mycobacterium tuberculosis infection
AU - Das, Gobardhan
AU - Vohra, H.
AU - Saha, B.
AU - Mishra, G. C.
PY - 2000/12/16
Y1 - 2000/12/16
N2 - The protection against Mycobacterium tuberculosis infection is mediated by T helper type-1 (Th1) cells. Infection of BALB/c mice with M. tuberculosis downregulates expression of a Th1-specific costimulatory molecule, M150, on the surface of infected macrophages. The proliferation of Th cells and Th1-cytokine production by these cells are higher in case of M. tuberculosis antigen presentation by uninfected macrophages than by infected macrophages. The difference in inducing interleukin(IL)-2 and interferon (IFN)-γ secretion is abolished by providing bystander costimulation through M150 on liposomes.
AB - The protection against Mycobacterium tuberculosis infection is mediated by T helper type-1 (Th1) cells. Infection of BALB/c mice with M. tuberculosis downregulates expression of a Th1-specific costimulatory molecule, M150, on the surface of infected macrophages. The proliferation of Th cells and Th1-cytokine production by these cells are higher in case of M. tuberculosis antigen presentation by uninfected macrophages than by infected macrophages. The difference in inducing interleukin(IL)-2 and interferon (IFN)-γ secretion is abolished by providing bystander costimulation through M150 on liposomes.
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U2 - 10.1046/j.1365-3083.2000.00808.x
DO - 10.1046/j.1365-3083.2000.00808.x
M3 - Article
C2 - 11119252
AN - SCOPUS:0033645638
VL - 52
SP - 515
EP - 518
JO - Scandinavian Journal of Immunology
JF - Scandinavian Journal of Immunology
SN - 0300-9475
IS - 5
ER -