Texas Youth Depression and Suicide Research Network (TX-YDSRN) research registry and learning healthcare network: Rationale, design, and baseline characteristics

Madhukar H. Trivedi; Abu Minhajuddin; Holli Slater; Regina Baronia; Joseph C. Blader; Jamon Blood; Ryan Brown; Cynthia Claassen; Melissa DeFilippis; David Farmer; Cynthia Garza; Jennifer L. Hughes; Beth D. Kennard; Israel Liberzon; Sarah Martin; Taryn L. Mayes; Jair C. Soares; Cesar A. Soutullo; Eric A. Storch; Sarah M. Wakefield

doi:10.1016/j.jad.2023.07.035

Texas Youth Depression and Suicide Research Network (TX-YDSRN) research registry and learning healthcare network: Rationale, design, and baseline characteristics

Madhukar H. Trivedi, Abu Minhajuddin, Holli Slater, Regina Baronia, Joseph C. Blader, Jamon Blood, Ryan Brown, Cynthia Claassen, Melissa DeFilippis, David Farmer, Cynthia Garza, Jennifer L. Hughes, Beth D. Kennard, Israel Liberzon, Sarah Martin, Taryn L. Mayes, Jair C. Soares, Cesar A. Soutullo, Eric A. Storch, Sarah M. Wakefield

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

BACKGROUND: American youth are seriously impacted by depression and suicide. The Texas Youth Depression and Suicide Research Network (TX-YDSRN) Participant Registry Study was initiated in 2020 to develop predictive models for treatment outcomes in youth with depression and/or suicidality. This report presents the study rationale, design and baseline characteristics of the first 1000 participants.

METHODS: TX-YDSRN consists of the Network Hub (coordinating center), 12 medical school "Nodes" (manage/implement study), each with 1-5 primary care, inpatient, and/or outpatient Sub-Sites (recruitment, data collection). Participants are 8-20-year-olds who receive treatment or screen positive for depression and/or suicidality. Baseline data include mood and suicidality symptoms, associated comorbidities, treatment history, services used, and social determinants of health. Subsequent assessments occur every two months for 24 months.

RESULTS: Among 1000 participants, 68.7 % were 12-17 years, 24.6 % were ≥ 18 years, and 6.7 % were < 12. Overall, 36.8 % were non-Hispanic Caucasian, 73.4 % were female, and 79.9 % had a primary depressive disorder. Nearly half of the sample reported ≥1 suicide attempt, with rates similar in youth 12-17 years old (49.9 %) and those 18 years and older (45.5 %); 29.9 % of children <12 reported at least one suicide attempt. Depression and anxiety scores were in the moderate-severe range for all age groups (Patient Health Questionnaire for Adolescents [PHQ-A]: 12.9 ± 6.4; Generalized Anxiety Disorder [GAD-7]: 11.3 ± 5.9).

LIMITATIONS: The sample includes youth who are receiving depression care at enrollment and may not be representative of non-diagnosed, non-treatment seeking youth.

CONCLUSIONS: The TX-YDSRN is one of the largest prospective longitudinal cohort registries designed to develop predictive models for outcome trajectories based on disorder heterogeneity, social determinants of health, and treatment availability.

Original language	English (US)
Pages (from-to)	88-99
Number of pages	12
Journal	Journal of Affective Disorders
Volume	340
DOIs	https://doi.org/10.1016/j.jad.2023.07.035
State	Published - Nov 1 2023

Keywords

Collaborative research network
Depression
Suicide
Treatment
Youth
Prospective Studies
Humans
Depression/therapy
Male
Texas/epidemiology
Delivery of Health Care
Adolescent
Female
Registries
Child

ASJC Scopus subject areas

Psychiatry and Mental health
Clinical Psychology

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10.1016/j.jad.2023.07.035

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Trivedi, M. H., Minhajuddin, A., Slater, H., Baronia, R., Blader, J. C., Blood, J., Brown, R., Claassen, C., DeFilippis, M., Farmer, D., Garza, C., Hughes, J. L., Kennard, B. D., Liberzon, I., Martin, S., Mayes, T. L., Soares, J. C., Soutullo, C. A., Storch, E. A., & Wakefield, S. M. (2023). Texas Youth Depression and Suicide Research Network (TX-YDSRN) research registry and learning healthcare network: Rationale, design, and baseline characteristics. Journal of Affective Disorders, 340, 88-99. https://doi.org/10.1016/j.jad.2023.07.035

Trivedi, MH, Minhajuddin, A, Slater, H, Baronia, R, Blader, JC, Blood, J, Brown, R, Claassen, C, DeFilippis, M, Farmer, D, Garza, C, Hughes, JL, Kennard, BD, Liberzon, I, Martin, S, Mayes, TL, Soares, JC, Soutullo, CA, Storch, EA & Wakefield, SM 2023, 'Texas Youth Depression and Suicide Research Network (TX-YDSRN) research registry and learning healthcare network: Rationale, design, and baseline characteristics', Journal of Affective Disorders, vol. 340, pp. 88-99. https://doi.org/10.1016/j.jad.2023.07.035

@article{60be4d1318034e8b8ffc25682280e7ff,

title = "Texas Youth Depression and Suicide Research Network (TX-YDSRN) research registry and learning healthcare network: Rationale, design, and baseline characteristics",

abstract = "BACKGROUND: American youth are seriously impacted by depression and suicide. The Texas Youth Depression and Suicide Research Network (TX-YDSRN) Participant Registry Study was initiated in 2020 to develop predictive models for treatment outcomes in youth with depression and/or suicidality. This report presents the study rationale, design and baseline characteristics of the first 1000 participants.METHODS: TX-YDSRN consists of the Network Hub (coordinating center), 12 medical school {"}Nodes{"} (manage/implement study), each with 1-5 primary care, inpatient, and/or outpatient Sub-Sites (recruitment, data collection). Participants are 8-20-year-olds who receive treatment or screen positive for depression and/or suicidality. Baseline data include mood and suicidality symptoms, associated comorbidities, treatment history, services used, and social determinants of health. Subsequent assessments occur every two months for 24 months.RESULTS: Among 1000 participants, 68.7 \% were 12-17 years, 24.6 \% were ≥ 18 years, and 6.7 \% were < 12. Overall, 36.8 \% were non-Hispanic Caucasian, 73.4 \% were female, and 79.9 \% had a primary depressive disorder. Nearly half of the sample reported ≥1 suicide attempt, with rates similar in youth 12-17 years old (49.9 \%) and those 18 years and older (45.5 \%); 29.9 \% of children <12 reported at least one suicide attempt. Depression and anxiety scores were in the moderate-severe range for all age groups (Patient Health Questionnaire for Adolescents [PHQ-A]: 12.9 ± 6.4; Generalized Anxiety Disorder [GAD-7]: 11.3 ± 5.9).LIMITATIONS: The sample includes youth who are receiving depression care at enrollment and may not be representative of non-diagnosed, non-treatment seeking youth.CONCLUSIONS: The TX-YDSRN is one of the largest prospective longitudinal cohort registries designed to develop predictive models for outcome trajectories based on disorder heterogeneity, social determinants of health, and treatment availability.",

keywords = "Collaborative research network, Depression, Suicide, Treatment, Youth, Prospective Studies, Humans, Depression/therapy, Male, Texas/epidemiology, Delivery of Health Care, Adolescent, Female, Registries, Child",

author = "Trivedi, \{Madhukar H.\} and Abu Minhajuddin and Holli Slater and Regina Baronia and Blader, \{Joseph C.\} and Jamon Blood and Ryan Brown and Cynthia Claassen and Melissa DeFilippis and David Farmer and Cynthia Garza and Hughes, \{Jennifer L.\} and Kennard, \{Beth D.\} and Israel Liberzon and Sarah Martin and Mayes, \{Taryn L.\} and Soares, \{Jair C.\} and Soutullo, \{Cesar A.\} and Storch, \{Eric A.\} and Wakefield, \{Sarah M.\}",

note = "Publisher Copyright: {\textcopyright} 2023",

year = "2023",

month = nov,

day = "1",

doi = "10.1016/j.jad.2023.07.035",

language = "English (US)",

volume = "340",

pages = "88--99",

journal = "Journal of Affective Disorders",

issn = "0165-0327",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Texas Youth Depression and Suicide Research Network (TX-YDSRN) research registry and learning healthcare network

T2 - Rationale, design, and baseline characteristics

AU - Trivedi, Madhukar H.

AU - Minhajuddin, Abu

AU - Slater, Holli

AU - Baronia, Regina

AU - Blader, Joseph C.

AU - Blood, Jamon

AU - Brown, Ryan

AU - Claassen, Cynthia

AU - DeFilippis, Melissa

AU - Farmer, David

AU - Garza, Cynthia

AU - Hughes, Jennifer L.

AU - Kennard, Beth D.

AU - Liberzon, Israel

AU - Martin, Sarah

AU - Mayes, Taryn L.

AU - Soares, Jair C.

AU - Soutullo, Cesar A.

AU - Storch, Eric A.

AU - Wakefield, Sarah M.

PY - 2023/11/1

Y1 - 2023/11/1

N2 - BACKGROUND: American youth are seriously impacted by depression and suicide. The Texas Youth Depression and Suicide Research Network (TX-YDSRN) Participant Registry Study was initiated in 2020 to develop predictive models for treatment outcomes in youth with depression and/or suicidality. This report presents the study rationale, design and baseline characteristics of the first 1000 participants.METHODS: TX-YDSRN consists of the Network Hub (coordinating center), 12 medical school "Nodes" (manage/implement study), each with 1-5 primary care, inpatient, and/or outpatient Sub-Sites (recruitment, data collection). Participants are 8-20-year-olds who receive treatment or screen positive for depression and/or suicidality. Baseline data include mood and suicidality symptoms, associated comorbidities, treatment history, services used, and social determinants of health. Subsequent assessments occur every two months for 24 months.RESULTS: Among 1000 participants, 68.7 % were 12-17 years, 24.6 % were ≥ 18 years, and 6.7 % were < 12. Overall, 36.8 % were non-Hispanic Caucasian, 73.4 % were female, and 79.9 % had a primary depressive disorder. Nearly half of the sample reported ≥1 suicide attempt, with rates similar in youth 12-17 years old (49.9 %) and those 18 years and older (45.5 %); 29.9 % of children <12 reported at least one suicide attempt. Depression and anxiety scores were in the moderate-severe range for all age groups (Patient Health Questionnaire for Adolescents [PHQ-A]: 12.9 ± 6.4; Generalized Anxiety Disorder [GAD-7]: 11.3 ± 5.9).LIMITATIONS: The sample includes youth who are receiving depression care at enrollment and may not be representative of non-diagnosed, non-treatment seeking youth.CONCLUSIONS: The TX-YDSRN is one of the largest prospective longitudinal cohort registries designed to develop predictive models for outcome trajectories based on disorder heterogeneity, social determinants of health, and treatment availability.

AB - BACKGROUND: American youth are seriously impacted by depression and suicide. The Texas Youth Depression and Suicide Research Network (TX-YDSRN) Participant Registry Study was initiated in 2020 to develop predictive models for treatment outcomes in youth with depression and/or suicidality. This report presents the study rationale, design and baseline characteristics of the first 1000 participants.METHODS: TX-YDSRN consists of the Network Hub (coordinating center), 12 medical school "Nodes" (manage/implement study), each with 1-5 primary care, inpatient, and/or outpatient Sub-Sites (recruitment, data collection). Participants are 8-20-year-olds who receive treatment or screen positive for depression and/or suicidality. Baseline data include mood and suicidality symptoms, associated comorbidities, treatment history, services used, and social determinants of health. Subsequent assessments occur every two months for 24 months.RESULTS: Among 1000 participants, 68.7 % were 12-17 years, 24.6 % were ≥ 18 years, and 6.7 % were < 12. Overall, 36.8 % were non-Hispanic Caucasian, 73.4 % were female, and 79.9 % had a primary depressive disorder. Nearly half of the sample reported ≥1 suicide attempt, with rates similar in youth 12-17 years old (49.9 %) and those 18 years and older (45.5 %); 29.9 % of children <12 reported at least one suicide attempt. Depression and anxiety scores were in the moderate-severe range for all age groups (Patient Health Questionnaire for Adolescents [PHQ-A]: 12.9 ± 6.4; Generalized Anxiety Disorder [GAD-7]: 11.3 ± 5.9).LIMITATIONS: The sample includes youth who are receiving depression care at enrollment and may not be representative of non-diagnosed, non-treatment seeking youth.CONCLUSIONS: The TX-YDSRN is one of the largest prospective longitudinal cohort registries designed to develop predictive models for outcome trajectories based on disorder heterogeneity, social determinants of health, and treatment availability.

KW - Collaborative research network

KW - Depression

KW - Suicide

KW - Treatment

KW - Youth

KW - Prospective Studies

KW - Humans

KW - Depression/therapy

KW - Male

KW - Texas/epidemiology

KW - Delivery of Health Care

KW - Adolescent

KW - Female

KW - Registries

KW - Child

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U2 - 10.1016/j.jad.2023.07.035

DO - 10.1016/j.jad.2023.07.035

M3 - Article

C2 - 37459975

AN - SCOPUS:85150353325

SN - 0165-0327

VL - 340

SP - 88

EP - 99

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

ER -

Texas Youth Depression and Suicide Research Network (TX-YDSRN) research registry and learning healthcare network: Rationale, design, and baseline characteristics

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