Tetrabenazine treatment for tardive dyskinesia: Assessment by randomized videotape protocol

William G. Ondo, Philip A. Hanna, Joseph Jankovic

Research output: Contribution to journalArticlepeer-review

134 Scopus citations


Objective: Tetrabenazine, a monoamine depleter and dopamine receptor blocker, is used to treat several hyperkinetic movement disorders. The authors studied the use of tetrabenazine for tardive dyskinesia. Method: Twenty patients with tardive dyskinesia (mean duration=43.7 months) were videotaped before and after tetrabenazine treatment. Randomized videotapes were scored with the motor subset of the modified Abnormal Involuntary Movement Scale (AIMS) by raters blind to pre- or posttreatment status. Results: One patient did not tolerate tetrabenazine owing to sedation. The remaining 19 were rated after a mean of 20.3 weeks at a mean tetrabenazine dose of 57.9 mg/day. There were significant improvements in mean scores on both the patient AIMS self-rating and the AIMS motor subset evaluated by the blind videotape raters. All 19 patients continued to take tetrabenazine after the study. Conclusions: Tetrabenazine was well tolerated and resulted in significant improvements in AIMS scores for patients with refractory tardive dyskinesia.

Original languageEnglish (US)
Pages (from-to)1279-1281
Number of pages3
JournalAmerican Journal of Psychiatry
Issue number8
StatePublished - Jan 1 1999

ASJC Scopus subject areas

  • Psychiatry and Mental health


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