Tetrabenazine treatment for stereotypies and tics associated with dementia

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Stereotypies are frequently reported in frontotemporal dementia. Their pathophysiology and optimal treatment are largely unexplored. The author reports seven cases of marked stereotype in patients with probable frontotemporal dementia who were treated with tetrabenazine, a monoamine inhibitor. All patients had near-complete resolution of stereotypy. Six patients stopped tetrabenazine at some point, with return of their stereotype within 24 hours, which again improved in the four who restarted therapy. Efficacy has not waned over time. Tetrabenazine dramatically improved stereotypies in patients with dementia. This observation could increase understanding of this interesting phenotype.

Original languageEnglish (US)
Pages (from-to)208-214
Number of pages7
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume24
Issue number2
DOIs
StatePublished - Jan 1 2012

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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