Testing effects of glatiramer acetate and fingolimod in an infectious model of CNS immune surveillance

Research output: Contribution to journalArticle

Cyd Castro-Rojas, Krystin Deason, Rehana Z. Hussain, Liat Hayardeny, Petra C. Cravens, Felix Yarovinsky, Todd N. Eagar, Benjamine Arellano, Olaf Stüve

Immune surveillance of the CNS is critical for preventing infections; however, there is no accepted experimental model to assess the risk of infection when utilizing disease-modifying agents. We tested two approved agents for patients with multiple sclerosis (MS), glatiramer acetate and fingolimod, in an experimental model of CNS immune surveillance. C57BL/6 mice were infected with the ME49 strain of the neuroinvasive parasite Toxoplasma gondii (T. gondii) and then treated with GA and fingolimod. Neither treatment affected host survival; however, differences were observed in parasite load and in leukocyte numbers in the brains of infected animals. Here we demonstrate that this model could be a useful tool for analyzing immune surveillance.

Original languageEnglish (US)
Pages (from-to)232-235
Number of pages4
JournalJournal of Neuroimmunology
Volume276
Issue number1-2
DOIs
StatePublished - Nov 15 2014

PMID: 25227585

PMCID: PMC4296723

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Testing effects of glatiramer acetate and fingolimod in an infectious model of CNS immune surveillance. / Castro-Rojas, Cyd; Deason, Krystin; Hussain, Rehana Z.; Hayardeny, Liat; Cravens, Petra C.; Yarovinsky, Felix; Eagar, Todd N.; Arellano, Benjamine; Stüve, Olaf.

In: Journal of Neuroimmunology, Vol. 276, No. 1-2, 15.11.2014, p. 232-235.

Research output: Contribution to journalArticle

Harvard

Castro-Rojas, C, Deason, K, Hussain, RZ, Hayardeny, L, Cravens, PC, Yarovinsky, F, Eagar, TN, Arellano, B & Stüve, O 2014, 'Testing effects of glatiramer acetate and fingolimod in an infectious model of CNS immune surveillance' Journal of Neuroimmunology, vol. 276, no. 1-2, pp. 232-235. https://doi.org/10.1016/j.jneuroim.2014.08.624

APA

Castro-Rojas, C., Deason, K., Hussain, R. Z., Hayardeny, L., Cravens, P. C., Yarovinsky, F., ... Stüve, O. (2014). Testing effects of glatiramer acetate and fingolimod in an infectious model of CNS immune surveillance. Journal of Neuroimmunology, 276(1-2), 232-235. https://doi.org/10.1016/j.jneuroim.2014.08.624

Vancouver

Castro-Rojas C, Deason K, Hussain RZ, Hayardeny L, Cravens PC, Yarovinsky F et al. Testing effects of glatiramer acetate and fingolimod in an infectious model of CNS immune surveillance. Journal of Neuroimmunology. 2014 Nov 15;276(1-2):232-235. https://doi.org/10.1016/j.jneuroim.2014.08.624

Author

Castro-Rojas, Cyd ; Deason, Krystin ; Hussain, Rehana Z. ; Hayardeny, Liat ; Cravens, Petra C. ; Yarovinsky, Felix ; Eagar, Todd N. ; Arellano, Benjamine ; Stüve, Olaf. / Testing effects of glatiramer acetate and fingolimod in an infectious model of CNS immune surveillance. In: Journal of Neuroimmunology. 2014 ; Vol. 276, No. 1-2. pp. 232-235.

BibTeX

@article{723e741fd4674a92a9d6203341646e4d,
title = "Testing effects of glatiramer acetate and fingolimod in an infectious model of CNS immune surveillance",
abstract = "Immune surveillance of the CNS is critical for preventing infections; however, there is no accepted experimental model to assess the risk of infection when utilizing disease-modifying agents. We tested two approved agents for patients with multiple sclerosis (MS), glatiramer acetate and fingolimod, in an experimental model of CNS immune surveillance. C57BL/6 mice were infected with the ME49 strain of the neuroinvasive parasite Toxoplasma gondii (T. gondii) and then treated with GA and fingolimod. Neither treatment affected host survival; however, differences were observed in parasite load and in leukocyte numbers in the brains of infected animals. Here we demonstrate that this model could be a useful tool for analyzing immune surveillance.",
keywords = "EAE, Experimental autoimmune encephalomyelitis, Immune surveillance, Toxoplasma gondii",
author = "Cyd Castro-Rojas and Krystin Deason and Hussain, {Rehana Z.} and Liat Hayardeny and Cravens, {Petra C.} and Felix Yarovinsky and Eagar, {Todd N.} and Benjamine Arellano and Olaf St{\"u}ve",
year = "2014",
month = "11",
day = "15",
doi = "10.1016/j.jneuroim.2014.08.624",
language = "English (US)",
volume = "276",
pages = "232--235",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Testing effects of glatiramer acetate and fingolimod in an infectious model of CNS immune surveillance

AU - Castro-Rojas, Cyd

AU - Deason, Krystin

AU - Hussain, Rehana Z.

AU - Hayardeny, Liat

AU - Cravens, Petra C.

AU - Yarovinsky, Felix

AU - Eagar, Todd N.

AU - Arellano, Benjamine

AU - Stüve, Olaf

PY - 2014/11/15

Y1 - 2014/11/15

N2 - Immune surveillance of the CNS is critical for preventing infections; however, there is no accepted experimental model to assess the risk of infection when utilizing disease-modifying agents. We tested two approved agents for patients with multiple sclerosis (MS), glatiramer acetate and fingolimod, in an experimental model of CNS immune surveillance. C57BL/6 mice were infected with the ME49 strain of the neuroinvasive parasite Toxoplasma gondii (T. gondii) and then treated with GA and fingolimod. Neither treatment affected host survival; however, differences were observed in parasite load and in leukocyte numbers in the brains of infected animals. Here we demonstrate that this model could be a useful tool for analyzing immune surveillance.

AB - Immune surveillance of the CNS is critical for preventing infections; however, there is no accepted experimental model to assess the risk of infection when utilizing disease-modifying agents. We tested two approved agents for patients with multiple sclerosis (MS), glatiramer acetate and fingolimod, in an experimental model of CNS immune surveillance. C57BL/6 mice were infected with the ME49 strain of the neuroinvasive parasite Toxoplasma gondii (T. gondii) and then treated with GA and fingolimod. Neither treatment affected host survival; however, differences were observed in parasite load and in leukocyte numbers in the brains of infected animals. Here we demonstrate that this model could be a useful tool for analyzing immune surveillance.

KW - EAE

KW - Experimental autoimmune encephalomyelitis

KW - Immune surveillance

KW - Toxoplasma gondii

UR - http://www.scopus.com/inward/record.url?scp=84908500152&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84908500152&partnerID=8YFLogxK

U2 - 10.1016/j.jneuroim.2014.08.624

DO - 10.1016/j.jneuroim.2014.08.624

M3 - Article

VL - 276

SP - 232

EP - 235

JO - Journal of Neuroimmunology

T2 - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

IS - 1-2

ER -

ID: 16807735