Tenuous airway in children with trisomy 21

Andrew L. De Jong, Marcelle Sulek, Michael Nihill, Newton Duncan, Ellen M. Friedman

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Multiple congenital anomalies are closely linked to Down syndrome (trisomy 21). Cardiac malformations are found in 40% of patients, a large number of whom will require a major surgical procedure. The importance of postextubation strider in these children is frequently underestimated. A retrospective review of 99 trisomy 21 patients who underwent cardiovascular surgery revealed postextubation strider in 24 (24.2%). Significant factors for the development of stridor included younger age (P=0.04), lower growth percentile for weight (P=0.03), and increased frequency of reintubation (P=0.04). Subglottic stenosis was found in 6 (6.1%). In 4 of these patients, an endotracheal tube of larger diameter than predicted for age was used. All 6 patients were less than the 10th percentile for weight. We conclude that Down syndrome patients deserve special considerations and modifications of standard intubation techniques for successful airway management.

Original languageEnglish (US)
Pages (from-to)345-350
Number of pages6
Issue number3
StatePublished - Mar 1 1997

ASJC Scopus subject areas

  • Otorhinolaryngology


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