Telomerase Therapy to Reverse Cardiovascular Senescence

Timo Z. Nazari-Shafti, John P. Cooke

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


Cellular senescence of endothelial cells plays an important role in the development of vascular lesions that ultimately lead to an atherosclerotic plaque. This review focuses on the age-related changes of endothelial and vascular smooth muscle cells that contribute to vascular disease and discusses potential new targets that could rejuvenate the vascular system and thereby prevent or delay atherosclerosis.

Original languageEnglish (US)
Pages (from-to)172-175
Number of pages4
JournalMethodist DeBakey cardiovascular journal
Issue number3
StatePublished - Jul 1 2015


  • aging
  • atherosclerosis
  • cellular senescence
  • endothelium
  • modified MRNA
  • prevention
  • telomerase

ASJC Scopus subject areas

  • Medicine(all)


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