Telomerase Therapy to Reverse Cardiovascular Senescence

Timo Z. Nazari-Shafti; John P. Cooke

doi:10.14797/mdcj-11-3-172

Telomerase Therapy to Reverse Cardiovascular Senescence

Timo Z. Nazari-Shafti, John P. Cooke

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

Cellular senescence of endothelial cells plays an important role in the development of vascular lesions that ultimately lead to an atherosclerotic plaque. This review focuses on the age-related changes of endothelial and vascular smooth muscle cells that contribute to vascular disease and discusses potential new targets that could rejuvenate the vascular system and thereby prevent or delay atherosclerosis.

Original language	English (US)
Pages (from-to)	172-175
Number of pages	4
Journal	Methodist DeBakey cardiovascular journal
Volume	11
Issue number	3
DOIs	https://doi.org/10.14797/mdcj-11-3-172
State	Published - Jul 1 2015

Keywords

aging
atherosclerosis
cellular senescence
endothelium
modified MRNA
prevention
telomerase

ASJC Scopus subject areas

Medicine(all)

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10.14797/mdcj-11-3-172

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title = "Telomerase Therapy to Reverse Cardiovascular Senescence",

abstract = "Cellular senescence of endothelial cells plays an important role in the development of vascular lesions that ultimately lead to an atherosclerotic plaque. This review focuses on the age-related changes of endothelial and vascular smooth muscle cells that contribute to vascular disease and discusses potential new targets that could rejuvenate the vascular system and thereby prevent or delay atherosclerosis.",

keywords = "aging, atherosclerosis, cellular senescence, endothelium, modified MRNA, prevention, telomerase",

author = "Nazari-Shafti, {Timo Z.} and Cooke, {John P.}",

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T1 - Telomerase Therapy to Reverse Cardiovascular Senescence

AU - Nazari-Shafti, Timo Z.

AU - Cooke, John P.

N1 - Copyright: This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Cellular senescence of endothelial cells plays an important role in the development of vascular lesions that ultimately lead to an atherosclerotic plaque. This review focuses on the age-related changes of endothelial and vascular smooth muscle cells that contribute to vascular disease and discusses potential new targets that could rejuvenate the vascular system and thereby prevent or delay atherosclerosis.

AB - Cellular senescence of endothelial cells plays an important role in the development of vascular lesions that ultimately lead to an atherosclerotic plaque. This review focuses on the age-related changes of endothelial and vascular smooth muscle cells that contribute to vascular disease and discusses potential new targets that could rejuvenate the vascular system and thereby prevent or delay atherosclerosis.

KW - aging

KW - atherosclerosis

KW - cellular senescence

KW - endothelium

KW - modified MRNA

KW - prevention

KW - telomerase

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M3 - Review article

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EP - 175

JO - Methodist DeBakey cardiovascular journal

JF - Methodist DeBakey cardiovascular journal

IS - 3

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Telomerase Therapy to Reverse Cardiovascular Senescence

Abstract

Keywords

ASJC Scopus subject areas

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