Telmisartan attenuates oxidative stress and renal fibrosis in streptozotocin induced diabetic mice with the alteration of angiotensin-(1-7) mas receptor expression associated with its PPAR-γ agonist action

Arun Prasath Lakshmanan, Kenichi Watanabe, Rajarajan A. Thandavarayan, Flori R. Sari, Meilei Harima, Vijayasree V. Giridharan, Vivian Soetikno, Makoto Kodama, Yoshifusa Aizawa

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

The beneficial effects of telmisartan on Angiotensin (Ang)-II mediated oxidative stress and renal fibrosis in streptozotocin (STZ)-induced diabetic nephropathy (DN) were studied. Thirty mice were divided into normal (NG), STZ-induced diabetic (DG) and telmisartan-treated diabetic (TG) groups. Compared with NG mice, DG mice showed significant up-regulations of AT-1R, TGF-β1, p-p38MAPK, p-MAPKAPK-2, p-Akt, p47phox, p67phox, gp91phox protein and collagen-III and all of these were significantly reversed in TG mice. The down-regulated protein expression of Ang-(1-7) mas receptor, ACE-2, PPAR-γ and PGC-1α were observed in DG mice and a significant up-regulation effect of telmisartan has been seen in the TG mice. Furthermore, TG mice showed reduced expression of fibronectin, production of superoxide radical as well as renal hypertrophy and fibrosis when compared with DG mice. These findings suggest that Ang-II plays a significant role in DN and telmisartan would be beneficial in reducing oxidative stress and fibrosis in STZ-induced DN.

Original languageEnglish (US)
Pages (from-to)575-584
Number of pages10
JournalFree Radical Research
Volume45
Issue number5
DOIs
StatePublished - May 2011

Keywords

  • Renin-angiotensin-aldosterone system
  • diabetic nephropathy
  • fibrosis
  • oxidative stress
  • telmisartan

ASJC Scopus subject areas

  • Biochemistry

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