TY - JOUR
T1 - Technologies for intrapericardial delivery of therapeutics and cells
AU - Filgueira, Carly S.
AU - Igo, Stephen R.
AU - Wang, Dennis K.
AU - Hirsch, Matteo
AU - Schulz, Daryl G.
AU - Bruckner, Brian A.
AU - Grattoni, Alessandro
N1 - Publisher Copyright:
© 2019
PY - 2019/11/1
Y1 - 2019/11/1
N2 - The pericardium, which surrounds the heart, provides a unique enclosed volume and a site for the delivery of agents to the heart and coronary arteries. While strategies for targeting the delivery of therapeutics to the heart are lacking, various technologies and nanodelivery approaches are emerging as promising methods for site specific delivery to increase therapeutic myocardial retention, efficacy, and bioactivity, while decreasing undesired systemic effects. Here, we provide a literature review of various approaches for intrapericardial delivery of agents. Emphasis is given to sustained delivery approaches (pumps and catheters) and localized release (patches, drug eluting stents, and support devices and meshes). Further, minimally invasive access techniques, pericardial access devices, pericardial washout and fluid analysis, as well as therapeutic and cell delivery vehicles are presented. Finally, several promising new therapeutic targets to treat heart diseases are highlighted.
AB - The pericardium, which surrounds the heart, provides a unique enclosed volume and a site for the delivery of agents to the heart and coronary arteries. While strategies for targeting the delivery of therapeutics to the heart are lacking, various technologies and nanodelivery approaches are emerging as promising methods for site specific delivery to increase therapeutic myocardial retention, efficacy, and bioactivity, while decreasing undesired systemic effects. Here, we provide a literature review of various approaches for intrapericardial delivery of agents. Emphasis is given to sustained delivery approaches (pumps and catheters) and localized release (patches, drug eluting stents, and support devices and meshes). Further, minimally invasive access techniques, pericardial access devices, pericardial washout and fluid analysis, as well as therapeutic and cell delivery vehicles are presented. Finally, several promising new therapeutic targets to treat heart diseases are highlighted.
KW - Local
KW - Pericardial access devices
KW - Pericardial delivery
KW - Pericardium
KW - Therapeutic and cell delivery vehicles
UR - http://www.scopus.com/inward/record.url?scp=85062056400&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85062056400&partnerID=8YFLogxK
U2 - 10.1016/j.addr.2019.02.006
DO - 10.1016/j.addr.2019.02.006
M3 - Review article
C2 - 30797957
AN - SCOPUS:85062056400
SN - 0169-409X
VL - 151-152
SP - 222
EP - 232
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
ER -