TY - JOUR
T1 - Teachings from the egg
T2 - New and unexpected functions of RNAs
AU - Kloc, Malgorzata
PY - 2009/10
Y1 - 2009/10
N2 - Localized mRNAs found in specific regions of somatic cells, germ cells, and embryos function through their protein translation products in cell polarization and development. Recent studies on Xenopus and Drosophila eggs and various somatic cells showed that some of the localized noncoding and coding RNAs play a structural (translation independent) role in maintaining the integrity of microtubule and microfilament cytoskeleton and/or may function in protein folding or as a scaffold for the assembly of cytoplasmic complexes essential for egg or embryo development. In addition, structural noncoding RNAs within the cell nucleus have been shown to be involved in the organization of chromatin, nuclear bodies, and DNA replication. The fact that some of the RNAs may have previously unforeseen structural functions, will change our view on traditional functions ofRNAsand will open new frontiers in the field of RNA studies and therapeutic development.
AB - Localized mRNAs found in specific regions of somatic cells, germ cells, and embryos function through their protein translation products in cell polarization and development. Recent studies on Xenopus and Drosophila eggs and various somatic cells showed that some of the localized noncoding and coding RNAs play a structural (translation independent) role in maintaining the integrity of microtubule and microfilament cytoskeleton and/or may function in protein folding or as a scaffold for the assembly of cytoplasmic complexes essential for egg or embryo development. In addition, structural noncoding RNAs within the cell nucleus have been shown to be involved in the organization of chromatin, nuclear bodies, and DNA replication. The fact that some of the RNAs may have previously unforeseen structural functions, will change our view on traditional functions ofRNAsand will open new frontiers in the field of RNA studies and therapeutic development.
UR - http://www.scopus.com/inward/record.url?scp=69749096186&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=69749096186&partnerID=8YFLogxK
U2 - 10.1002/mrd.21043
DO - 10.1002/mrd.21043
M3 - Article
C2 - 19422043
AN - SCOPUS:69749096186
SN - 1040-452X
VL - 76
SP - 922
EP - 932
JO - Molecular Reproduction and Development
JF - Molecular Reproduction and Development
IS - 10
ER -