TCR cross-linking induces CTL death via internal action of TNF

Jin Wang, Stephen A. Stohlman, Gunther Dennert

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

TCR-mediated stimulation can result in either activation or apoptosis, raising the question of what the mechanisms of these opposing effects might be. Here we demonstrate that microinjection of Ab specific for TNF inhibits activation-induced cell death, implicating TNF in anti-CD3-induced apoptosis. Induction of CTL in the presence of antisense TNF oligodeoxynucleotides inhibits TNF secretion and cell death after stimulation with anti-CD3. Incubation of cells with IL-2 for 48 h before stimulation protects from anti- CD3-induced death, whereas the presence of IL-2 during anti-CD3 treatment is without effect.

Original languageEnglish (US)
Pages (from-to)3824-3832
Number of pages9
JournalJournal of Immunology
Volume152
Issue number8
StatePublished - Apr 15 1994

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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