T‐Cell Epitopes on the Human Acetylcholine Receptor α‐Subunit Residues 10‐84 in Myasthenia Gravis

R. ÅHLBERG, Q. YI, H. ENG, R. PIRSKANEN, A. K. LEFVERT

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

In myasthenia gravis the production of anti‐acetylcholine receptor antibodies is modulated by acetylcholine receptor‐specific T cells. Most B‐and T‐cell epitopes are located on the α‐subunit of the receptor. In order to map the fine specificity of the antigen‐specific T cells in myasthenia gravis, T‐cell stimulation in response to 70 hexapeptides was studied in 24 patients and 24 healthy individuals. The hexapeptides overlapped with one amino acid and represented residues 10‐84 of the NH2‐terminal part of the α‐subunit of the receptor. The IFN‐γ secretion from single T cells was used to detect T‐cell stimulation. A significanl difference in the T‐cell response to several of the peptides was found between patients and healthy controls. The majority of the hexapeptides induced T‐cell stimulation in at least one of the patients. Peptidc‐induced T‐cell stimulation was evident in all but one of the patients. The results indicate that different epitopes and multiple T‐cell clones are involved in the T‐cell recognition of the acetylcholine receptor.

Original languageEnglish (US)
Pages (from-to)435-442
Number of pages8
JournalScandinavian Journal of Immunology
Volume36
Issue number3
DOIs
StatePublished - Sep 1992

ASJC Scopus subject areas

  • Immunology

Fingerprint Dive into the research topics of 'T‐Cell Epitopes on the Human Acetylcholine Receptor α‐Subunit Residues 10‐84 in Myasthenia Gravis'. Together they form a unique fingerprint.

Cite this