Targeting vascular endothelial growth factor in angina therapy

Munir Boodhwani, Basel Ramlawi, Roger J. Laham, Frank W. Sellke

Research output: Contribution to journalReview article

Abstract

Despite tremendous success of growth factor therapy in animal models, clinical trials have demonstrated minimal success. Vascular endothelial growth factors are perhaps the most potent inducers of angiogenesis in these animal models. This review outlines the biology of vascular endothelial growth factors in the context of myocardial angiogenesis with an emphasis on its effects on the endothelium. It also provides an overview of delivery strategies and summarises the preclinical and clinical evidence relating to exogenous growth factor delivery for myocardial angiogenesis with an emphasis on the key future challenges.

Original languageEnglish (US)
Pages (from-to)5-14
Number of pages10
JournalExpert Opinion on Therapeutic Targets
Volume10
Issue number1
DOIs
StatePublished - Feb 1 2006

Keywords

  • Angiogenesis
  • Clinical trial
  • Endothelium
  • Myocardial ischaemia
  • Vascular endothelial growth factor (VEGF)

ASJC Scopus subject areas

  • Molecular Medicine
  • Biochemistry, Genetics and Molecular Biology(all)

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