Targeting the thyroid gland with thyroid-stimulating hormone (TSH)-nanoliposomes

Donatella Paolino; Donato Cosco; Marco Gaspari; Marilena Celano; Joy Wolfram; Pasquale Voce; Efisio Puxeddu; Sebastiano Filetti; Christian Celia; Mauro Ferrari; Diego Russo; Massimo Fresta

doi:10.1016/j.biomaterials.2014.04.088

Targeting the thyroid gland with thyroid-stimulating hormone (TSH)-nanoliposomes

Donatella Paolino, Donato Cosco, Marco Gaspari, Marilena Celano, Joy Wolfram, Pasquale Voce, Efisio Puxeddu, Sebastiano Filetti, Christian Celia, Mauro Ferrari, Diego Russo, Massimo Fresta

Research output: Contribution to journal › Article › peer-review

95 Scopus citations

Abstract

Various tissue-specific antibodies have been attached to nanoparticles to obtain targeted delivery. In particular, nanodelivery systems with selectivity for breast, prostate and cancer tissue have been developed. Here, we have developed a nanodelivery system that targets the thyroid gland. Nanoliposomes have been conjugated to the thyroid-stimulating hormone (TSH), which binds to the TSH receptor (TSHr) on the surface of thyrocytes. The results indicate that the intracellular uptake of TSH-nanoliposomes is increased in cells expressing the TSHr. The accumulation of targeted nanoliposomes in the thyroid gland following intravenous injection was 3.5-fold higher in comparison to untargeted nanoliposomes. Furthermore, TSH-nanoliposomes encapsulated with gemcitabine showed improved anticancer efficacy invitro and in a tumor model of follicular thyroid carcinoma. This drug delivery system could be used for the treatment of a broad spectrum of thyroid diseases to reduce side effects and improve therapeutic efficacy.

Original language	English (US)
Pages (from-to)	7101-7109
Number of pages	9
Journal	Biomaterials
Volume	35
Issue number	25
DOIs	https://doi.org/10.1016/j.biomaterials.2014.04.088
State	Published - Aug 2014

Keywords

Nanoliposomes
Nanoparticles
Targeting
Thyroid cancer
Thyroid gland

ASJC Scopus subject areas

Biomaterials
Bioengineering
Ceramics and Composites
Mechanics of Materials
Biophysics

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10.1016/j.biomaterials.2014.04.088

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title = "Targeting the thyroid gland with thyroid-stimulating hormone (TSH)-nanoliposomes",

abstract = "Various tissue-specific antibodies have been attached to nanoparticles to obtain targeted delivery. In particular, nanodelivery systems with selectivity for breast, prostate and cancer tissue have been developed. Here, we have developed a nanodelivery system that targets the thyroid gland. Nanoliposomes have been conjugated to the thyroid-stimulating hormone (TSH), which binds to the TSH receptor (TSHr) on the surface of thyrocytes. The results indicate that the intracellular uptake of TSH-nanoliposomes is increased in cells expressing the TSHr. The accumulation of targeted nanoliposomes in the thyroid gland following intravenous injection was 3.5-fold higher in comparison to untargeted nanoliposomes. Furthermore, TSH-nanoliposomes encapsulated with gemcitabine showed improved anticancer efficacy invitro and in a tumor model of follicular thyroid carcinoma. This drug delivery system could be used for the treatment of a broad spectrum of thyroid diseases to reduce side effects and improve therapeutic efficacy.",

keywords = "Nanoliposomes, Nanoparticles, Targeting, Thyroid cancer, Thyroid gland",

author = "Donatella Paolino and Donato Cosco and Marco Gaspari and Marilena Celano and Joy Wolfram and Pasquale Voce and Efisio Puxeddu and Sebastiano Filetti and Christian Celia and Mauro Ferrari and Diego Russo and Massimo Fresta",

note = "Funding Information: This paper was financially supported by the PON a3\_00359 (IRC-FSH) Centro Interregionale per la Sicurezza degli Alimenti e la Salute , PRIN 2010-2011-prot . 2010H834LS\_006 and Fondazione Umberto Di Mario ONLUS . ",

year = "2014",

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doi = "10.1016/j.biomaterials.2014.04.088",

language = "English (US)",

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journal = "Biomaterials",

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AU - Paolino, Donatella

AU - Cosco, Donato

AU - Gaspari, Marco

AU - Celano, Marilena

AU - Wolfram, Joy

AU - Voce, Pasquale

AU - Puxeddu, Efisio

AU - Filetti, Sebastiano

AU - Celia, Christian

AU - Ferrari, Mauro

AU - Russo, Diego

AU - Fresta, Massimo

N1 - Funding Information: This paper was financially supported by the PON a3_00359 (IRC-FSH) Centro Interregionale per la Sicurezza degli Alimenti e la Salute , PRIN 2010-2011-prot . 2010H834LS_006 and Fondazione Umberto Di Mario ONLUS .

PY - 2014/8

Y1 - 2014/8

N2 - Various tissue-specific antibodies have been attached to nanoparticles to obtain targeted delivery. In particular, nanodelivery systems with selectivity for breast, prostate and cancer tissue have been developed. Here, we have developed a nanodelivery system that targets the thyroid gland. Nanoliposomes have been conjugated to the thyroid-stimulating hormone (TSH), which binds to the TSH receptor (TSHr) on the surface of thyrocytes. The results indicate that the intracellular uptake of TSH-nanoliposomes is increased in cells expressing the TSHr. The accumulation of targeted nanoliposomes in the thyroid gland following intravenous injection was 3.5-fold higher in comparison to untargeted nanoliposomes. Furthermore, TSH-nanoliposomes encapsulated with gemcitabine showed improved anticancer efficacy invitro and in a tumor model of follicular thyroid carcinoma. This drug delivery system could be used for the treatment of a broad spectrum of thyroid diseases to reduce side effects and improve therapeutic efficacy.

AB - Various tissue-specific antibodies have been attached to nanoparticles to obtain targeted delivery. In particular, nanodelivery systems with selectivity for breast, prostate and cancer tissue have been developed. Here, we have developed a nanodelivery system that targets the thyroid gland. Nanoliposomes have been conjugated to the thyroid-stimulating hormone (TSH), which binds to the TSH receptor (TSHr) on the surface of thyrocytes. The results indicate that the intracellular uptake of TSH-nanoliposomes is increased in cells expressing the TSHr. The accumulation of targeted nanoliposomes in the thyroid gland following intravenous injection was 3.5-fold higher in comparison to untargeted nanoliposomes. Furthermore, TSH-nanoliposomes encapsulated with gemcitabine showed improved anticancer efficacy invitro and in a tumor model of follicular thyroid carcinoma. This drug delivery system could be used for the treatment of a broad spectrum of thyroid diseases to reduce side effects and improve therapeutic efficacy.

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KW - Targeting

KW - Thyroid cancer

KW - Thyroid gland

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Targeting the thyroid gland with thyroid-stimulating hormone (TSH)-nanoliposomes

Abstract

Keywords

ASJC Scopus subject areas

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