Targeting the PI3-Kinase/Akt/mTOR Signaling Pathway

Burhan Hassan, Argun Akcakanat, Ashley M. Holder, Funda Meric-Bernstam

Research output: Contribution to journalReview articlepeer-review

157 Scopus citations


This article presents an overview of the PI3K/Akt/mTOR signaling pathway. As a central regulator of cell growth, protein translation, survival, and metabolism, activation of this signaling pathway contributes to the pathogenesis of many tumor types. Biochemical and genetic aberrations of this pathway observed in various cancer types are explored. Last, pathway inhibitors both in development and already approved by the Food and Drug Administration are discussed.

Original languageEnglish (US)
Pages (from-to)641-664
Number of pages24
JournalSurgical Oncology Clinics of North America
Issue number4
StatePublished - Oct 2013


  • Cell signaling
  • Molecular targeted therapy
  • PI3K/Akt/mTOR signaling pathway
  • PTEN

ASJC Scopus subject areas

  • Surgery
  • Oncology


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