Targeting PES1 for restoring the ERα/ERβratio in breast cancer

Christoforos Thomas, Jan Åke Gustafsson

Research output: Contribution to journalComment/debate

12 Scopus citations

Abstract

Alteration of the ERα/ERβ balance is a critical step in breast cancer development and progression, and selective restoration of the activity of estrogen receptors has been proposed as one of the major therapeutic approaches for breast cancer. In this issue of JCI, Cheng et al. show that, by differentially modulating the stability of ERα and ERβ, PES1 increases the ERα/ERβ ratio and triggers breast tumor growth. These findings highlight PES1 as a potential target for the treatment of breast cancer.

Original languageEnglish (US)
Pages (from-to)2771-2773
Number of pages3
JournalJournal of Clinical Investigation
Volume122
Issue number8
DOIs
StatePublished - Aug 1 2012

ASJC Scopus subject areas

  • Medicine(all)

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