Targeting of nanoparticles: folate receptor.

Sumith A. Kularatne, Philip Low

Research output: Contribution to journalArticle

85 Scopus citations

Abstract

Nanoparticulate medicines offer the advantage of allowing delivery of large quantities of unmodified drug within the same particle. Nanoparticle uptake by cancer cells can, however, be compromised due to the large size and hydrophilicity of the particle. To circumvent cell penetration problems and simultaneously improve tumor specificity, nanoparticulate medicines have been linked to targeting ligands that bind to malignant cell surfaces and enter cells by receptor-mediated endocytosis. In this chapter, we summarize multiple methods for delivering nanoparticles into cancer cells by folate receptor-mediated endocytosis, devoting special emphasis to folate-targeted liposomes. Folate receptor-mediated endocytosis has emerged as an attractive strategy for nanoparticle delivery due to both overexpression of the folate receptor on cancer cells and the rapid internalization of the receptor by receptor-mediated endocytosis.

Original languageEnglish (US)
Pages (from-to)249-265
Number of pages17
JournalMethods in molecular biology (Clifton, N.J.)
Volume624
DOIs
StatePublished - Jan 1 2010

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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