@article{f0c2beb16bf24827b8878e115adfffcc,
title = "Targeting Nuclear Receptors for Cancer Therapy: Premises, Promises, and Challenges",
abstract = "Nuclear receptors are a family of transcription factors localized in cell nuclei, sensing specific ligands and fine-tuning a variety of cell physiological events. They have been intensively investigated in cancer biology. With their excellent properties of druggability and actionability, nuclear receptors have demonstrated much promise as novel therapeutic targets for different cancer types. Accumulating evidence has highlighted the essential roles of certain nuclear receptors in tumor immunology, suggesting the possibility for them to serve as cancer immunotherapeutic targets. Here, we summarize the roles of nuclear receptors in cancer biology and tumor immunology, and underscore the current advances of clinical trials for nuclear receptor-based cancer therapeutics.",
keywords = "cancer therapy, nuclear receptors, tumor immunology",
author = "Zhengnan Yang and Gimple, {Ryan C.} and Nianxin Zhou and Linjie Zhao and Gustafsson, {Jan {\AA}ke} and Shengtao Zhou",
note = "Funding Information: This work was supported by grants from the National Natural Science Foundation of China (grant #81822034, grant #81821002, and grant #81773119), National Key Research and Development Program of China (grant #2018YFA0109200 and grant #2017YFA0106800), Sichuan Science-Technology International Cooperation Project (grant #2019YFH0144), Direct Scientific Research Grants from West China Second Hospital, Sichuan University (grant #KS021 and grant #K1907), the Robert A. Welch Foundation (grant #E-0004), the Swedish Cancer Foundation, the Center for Innovative Medicine, the Novo Nordisk Fund, and grants provided by National Institutes of Health (CA217065). Figures were created with BioRender.com. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = jun,
doi = "10.1016/j.trecan.2020.11.007",
language = "English (US)",
volume = "7",
pages = "541--556",
journal = "Trends in Cancer",
issn = "2405-8033",
publisher = "Cell Press",
number = "6",
}