Targeting Nuclear Receptors for Cancer Therapy: Premises, Promises, and Challenges

Zhengnan Yang, Ryan C. Gimple, Nianxin Zhou, Linjie Zhao, Jan Åke Gustafsson, Shengtao Zhou

Research output: Contribution to journalReview articlepeer-review

Abstract

Nuclear receptors are a family of transcription factors localized in cell nuclei, sensing specific ligands and fine-tuning a variety of cell physiological events. They have been intensively investigated in cancer biology. With their excellent properties of druggability and actionability, nuclear receptors have demonstrated much promise as novel therapeutic targets for different cancer types. Accumulating evidence has highlighted the essential roles of certain nuclear receptors in tumor immunology, suggesting the possibility for them to serve as cancer immunotherapeutic targets. Here, we summarize the roles of nuclear receptors in cancer biology and tumor immunology, and underscore the current advances of clinical trials for nuclear receptor-based cancer therapeutics.

Original languageEnglish (US)
Pages (from-to)541-556
Number of pages16
JournalTrends in Cancer
Volume7
Issue number6
DOIs
StatePublished - Jun 2021

Keywords

  • cancer therapy
  • nuclear receptors
  • tumor immunology

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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