Targeting liver X receptors in cancer therapeutics

Chin Yo Lin, Jan Åke Gustafsson

Research output: Contribution to journalReview articlepeer-review

135 Scopus citations


Members of the nuclear receptor superfamily of ligand-dependent transcription factors carry out vital cellular functions and are highly druggable therapeutic targets. Liver X receptors (LXRs) are nuclear receptor family members that function in cholesterol transport, glucose metabolism and the modulation of inflammatory responses. There is now accumulating evidence to support the involvement of LXRs in a variety of malignancies and the potential efficacy of their ligands in these diseases. This Review summarizes the discovery and characterization of LXRs and their ligands, their effects and mechanisms in preclinical cancer models, and the future directions of basic and translational LXR research in cancer therapeutics.

Original languageEnglish (US)
Pages (from-to)216-224
Number of pages9
JournalNature Reviews Cancer
Issue number4
StatePublished - Apr 27 2015

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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