Targeting LFA-1 and CD154 suppresses the in vivo activation and development of cytolytic (CD4-idependent) CD8⁺ T cells

Keyphrases

• CD8+ T Cells 100%
• LFA-1 100%
• In Vitro Activation 100%
• Cytolytic 100%
• In Vivo Development 100%
• CD154 100%
• Liver 80%
• Allograft Survival 80%
• Hepatocytes 80%
• Allograft 40%
• CD8+ 40%
• Anti-CD154 40%
• Costimulation 40%
• Immunotherapeutic Strategy 40%
• Infiltrating Cells 40%
• Rejectors 40%
• CD40/CD154 40%
• Knock-in Mouse Model 20%
• Cell Population 20%
• Synergistic Effect 20%
• Adoptive Transfer 20%
• Effector Function 20%
• Long-term Survival 20%
• T Cell Activation Markers 20%
• Adhesion Molecules 20%
• Inflammatory Cells 20%
• Cytotoxic T Cells 20%
• Alloreactive 20%
• Early Development 20%
• Delayed Hypersensitivity 20%
• Allograft Acceptance 20%
• Engraft 20%
• Immunoregulation 20%
• CD43 20%
• CD4+ Regulatory T Cells 20%
• CD8+ T Cell Infiltration 20%
• CD69 20%
• Naive CD8+ T Cells 20%
• CD103 20%

Immunology and Microbiology

• Allograft 100%
• Cytotoxic T-Cell 100%
• CD4 100%
• Lymphocyte Function-Associated Antigen 1 100%
• CD154 100%
• Immunotherapy 42%
• CD8 28%
• T Cell Activation 28%
• Knockout Mouse 14%
• Cell Population 14%
• Cytotoxic T Cell 14%
• Immunoregulation 14%
• Regulatory T Cell 14%
• Inflammatory Cell 14%
• Long Term Survival 14%
• Cell Adhesion Proteins 14%
• T Cell Development 14%
• Delayed Hypersensitivity 14%
• CD43 14%
• CD69 14%