Targeting infiltrating immune cells to improve articular cartilage regeneration

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Francesca Taraballi, G. Bauza, L. Francis, A. Zhang, M. Hopson, S. Shaikh, F. Cabrera, X. Wang, A. Shi, Dale J. Hamilton, Patrick McCulloch, Ennio Tasciotti

Statement of Purpose: The treatment of pathologies, like osteoarthritis (OA) associated to the loss of cartilage due to traumatic injuries is still lacking an effective therapy. Articular cartilage has very limited intrinsic healing possibilities 1 . Consequently, traumatic and degenerative lesions of articular cartilage eventually progress to osteoarthritis, a leading source of disability worldwide. Full thickness chondral defects are the more frequent traumatic injuries resulting in OA. Currently focal lesions treatments have proposed different regenerative approaches that aim to restore the homeostasis of the damaged tissue. The challenge is high: we need to develop a tissue engineering solution capable of concurrently stimulating the hyaline cartilage formation while preventing inflammatory and fibrotic reactions that results in OA. We hypothesize that a biomaterial able to control the inflammatory environment (tuning the infiltrating macrophages toward an anti-inflammatory phenotype) of the cartilage will promote cartilage regrowth limiting post-traumatic osteoarthritis degeneration 2 (Figure 1).

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
Volume40
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Other

Other42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

Cite this

Standard

Targeting infiltrating immune cells to improve articular cartilage regeneration. / Taraballi, Francesca; Bauza, G.; Francis, L.; Zhang, A.; Hopson, M.; Shaikh, S.; Cabrera, F.; Wang, X.; Shi, A.; Hamilton, Dale J.; McCulloch, Patrick; Tasciotti, Ennio.

Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Vol. 40 Society for Biomaterials, 2019.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Harvard

Taraballi, F, Bauza, G, Francis, L, Zhang, A, Hopson, M, Shaikh, S, Cabrera, F, Wang, X, Shi, A, Hamilton, DJ, McCulloch, P & Tasciotti, E 2019, Targeting infiltrating immune cells to improve articular cartilage regeneration. in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. vol. 40, Society for Biomaterials, 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, Seattle, United States, 4/3/19.

APA

Taraballi, F., Bauza, G., Francis, L., Zhang, A., Hopson, M., Shaikh, S., ... Tasciotti, E. (2019). Targeting infiltrating immune cells to improve articular cartilage regeneration. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Vol. 40). Society for Biomaterials.

Vancouver

Taraballi F, Bauza G, Francis L, Zhang A, Hopson M, Shaikh S et al. Targeting infiltrating immune cells to improve articular cartilage regeneration. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Vol. 40. Society for Biomaterials. 2019

Author

Taraballi, Francesca ; Bauza, G. ; Francis, L. ; Zhang, A. ; Hopson, M. ; Shaikh, S. ; Cabrera, F. ; Wang, X. ; Shi, A. ; Hamilton, Dale J. ; McCulloch, Patrick ; Tasciotti, Ennio. / Targeting infiltrating immune cells to improve articular cartilage regeneration. Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Vol. 40 Society for Biomaterials, 2019.

BibTeX

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title = "Targeting infiltrating immune cells to improve articular cartilage regeneration",
abstract = "Statement of Purpose: The treatment of pathologies, like osteoarthritis (OA) associated to the loss of cartilage due to traumatic injuries is still lacking an effective therapy. Articular cartilage has very limited intrinsic healing possibilities 1 . Consequently, traumatic and degenerative lesions of articular cartilage eventually progress to osteoarthritis, a leading source of disability worldwide. Full thickness chondral defects are the more frequent traumatic injuries resulting in OA. Currently focal lesions treatments have proposed different regenerative approaches that aim to restore the homeostasis of the damaged tissue. The challenge is high: we need to develop a tissue engineering solution capable of concurrently stimulating the hyaline cartilage formation while preventing inflammatory and fibrotic reactions that results in OA. We hypothesize that a biomaterial able to control the inflammatory environment (tuning the infiltrating macrophages toward an anti-inflammatory phenotype) of the cartilage will promote cartilage regrowth limiting post-traumatic osteoarthritis degeneration 2 (Figure 1).",
author = "Francesca Taraballi and G. Bauza and L. Francis and A. Zhang and M. Hopson and S. Shaikh and F. Cabrera and X. Wang and A. Shi and Hamilton, {Dale J.} and Patrick McCulloch and Ennio Tasciotti",
year = "2019",
month = "1",
day = "1",
language = "English (US)",
volume = "40",
booktitle = "Society for Biomaterials Annual Meeting and Exposition 2019",
publisher = "Society for Biomaterials",

}

RIS

TY - GEN

T1 - Targeting infiltrating immune cells to improve articular cartilage regeneration

AU - Taraballi, Francesca

AU - Bauza, G.

AU - Francis, L.

AU - Zhang, A.

AU - Hopson, M.

AU - Shaikh, S.

AU - Cabrera, F.

AU - Wang, X.

AU - Shi, A.

AU - Hamilton, Dale J.

AU - McCulloch, Patrick

AU - Tasciotti, Ennio

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Statement of Purpose: The treatment of pathologies, like osteoarthritis (OA) associated to the loss of cartilage due to traumatic injuries is still lacking an effective therapy. Articular cartilage has very limited intrinsic healing possibilities 1 . Consequently, traumatic and degenerative lesions of articular cartilage eventually progress to osteoarthritis, a leading source of disability worldwide. Full thickness chondral defects are the more frequent traumatic injuries resulting in OA. Currently focal lesions treatments have proposed different regenerative approaches that aim to restore the homeostasis of the damaged tissue. The challenge is high: we need to develop a tissue engineering solution capable of concurrently stimulating the hyaline cartilage formation while preventing inflammatory and fibrotic reactions that results in OA. We hypothesize that a biomaterial able to control the inflammatory environment (tuning the infiltrating macrophages toward an anti-inflammatory phenotype) of the cartilage will promote cartilage regrowth limiting post-traumatic osteoarthritis degeneration 2 (Figure 1).

AB - Statement of Purpose: The treatment of pathologies, like osteoarthritis (OA) associated to the loss of cartilage due to traumatic injuries is still lacking an effective therapy. Articular cartilage has very limited intrinsic healing possibilities 1 . Consequently, traumatic and degenerative lesions of articular cartilage eventually progress to osteoarthritis, a leading source of disability worldwide. Full thickness chondral defects are the more frequent traumatic injuries resulting in OA. Currently focal lesions treatments have proposed different regenerative approaches that aim to restore the homeostasis of the damaged tissue. The challenge is high: we need to develop a tissue engineering solution capable of concurrently stimulating the hyaline cartilage formation while preventing inflammatory and fibrotic reactions that results in OA. We hypothesize that a biomaterial able to control the inflammatory environment (tuning the infiltrating macrophages toward an anti-inflammatory phenotype) of the cartilage will promote cartilage regrowth limiting post-traumatic osteoarthritis degeneration 2 (Figure 1).

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M3 - Conference contribution

VL - 40

BT - Society for Biomaterials Annual Meeting and Exposition 2019

PB - Society for Biomaterials

ER -

ID: 48699084