Targeting infiltrating immune cells to improve articular cartilage regeneration

Francesca Taraballi, G. Bauza, L. Francis, Aijun Zhang, M. Hopson, S. Shaikh, F. Cabrera, X. Wang, A. Shi, Dale J. Hamilton, Patrick McCulloch, Ennio Tasciotti

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: The treatment of pathologies, like osteoarthritis (OA) associated to the loss of cartilage due to traumatic injuries is still lacking an effective therapy. Articular cartilage has very limited intrinsic healing possibilities 1 . Consequently, traumatic and degenerative lesions of articular cartilage eventually progress to osteoarthritis, a leading source of disability worldwide. Full thickness chondral defects are the more frequent traumatic injuries resulting in OA. Currently focal lesions treatments have proposed different regenerative approaches that aim to restore the homeostasis of the damaged tissue. The challenge is high: we need to develop a tissue engineering solution capable of concurrently stimulating the hyaline cartilage formation while preventing inflammatory and fibrotic reactions that results in OA. We hypothesize that a biomaterial able to control the inflammatory environment (tuning the infiltrating macrophages toward an anti-inflammatory phenotype) of the cartilage will promote cartilage regrowth limiting post-traumatic osteoarthritis degeneration 2 (Figure 1).

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
Volume40
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Other

Other42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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  • Cite this

    Taraballi, F., Bauza, G., Francis, L., Zhang, A., Hopson, M., Shaikh, S., Cabrera, F., Wang, X., Shi, A., Hamilton, D. J., McCulloch, P., & Tasciotti, E. (2019). Targeting infiltrating immune cells to improve articular cartilage regeneration. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Vol. 40). Society for Biomaterials.