TY - GEN
T1 - Targeting infiltrating immune cells to improve articular cartilage regeneration
AU - Taraballi, F.
AU - Bauza, G.
AU - Francis, L.
AU - Zhang, A.
AU - Hopson, M.
AU - Shaikh, S.
AU - Cabrera, F.
AU - Wang, X.
AU - Shi, A.
AU - Hamilton, D.
AU - McCulloch, P.
AU - Tasciotti, Ennio
N1 - Publisher Copyright:
© 2019 Omnipress - All rights reserved.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019
Y1 - 2019
N2 - Statement of Purpose: The treatment of pathologies, like osteoarthritis (OA) associated to the loss of cartilage due to traumatic injuries is still lacking an effective therapy. Articular cartilage has very limited intrinsic healing possibilities1. Consequently, traumatic and degenerative lesions of articular cartilage eventually progress to osteoarthritis, a leading source of disability worldwide. Full thickness chondral defects are the more frequent traumatic injuries resulting in OA. Currently focal lesions treatments have proposed different regenerative approaches that aim to restore the homeostasis of the damaged tissue. The challenge is high: we need to develop a tissue engineering solution capable of concurrently stimulating the hyaline cartilage formation while preventing inflammatory and fibrotic reactions that results in OA. We hypothesize that a biomaterial able to control the inflammatory environment (tuning the infiltrating macrophages toward an anti-inflammatory phenotype) of the cartilage will promote cartilage regrowth limiting post-traumatic osteoarthritis degeneration2 (Figure 1).
AB - Statement of Purpose: The treatment of pathologies, like osteoarthritis (OA) associated to the loss of cartilage due to traumatic injuries is still lacking an effective therapy. Articular cartilage has very limited intrinsic healing possibilities1. Consequently, traumatic and degenerative lesions of articular cartilage eventually progress to osteoarthritis, a leading source of disability worldwide. Full thickness chondral defects are the more frequent traumatic injuries resulting in OA. Currently focal lesions treatments have proposed different regenerative approaches that aim to restore the homeostasis of the damaged tissue. The challenge is high: we need to develop a tissue engineering solution capable of concurrently stimulating the hyaline cartilage formation while preventing inflammatory and fibrotic reactions that results in OA. We hypothesize that a biomaterial able to control the inflammatory environment (tuning the infiltrating macrophages toward an anti-inflammatory phenotype) of the cartilage will promote cartilage regrowth limiting post-traumatic osteoarthritis degeneration2 (Figure 1).
UR - http://www.scopus.com/inward/record.url?scp=85065404892&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85065404892&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85065404892
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
SP - 710
BT - Society for Biomaterials Annual Meeting and Exposition 2019
PB - Society for Biomaterials
T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Y2 - 3 April 2019 through 6 April 2019
ER -