Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion

Rui Su; Lei Dong; Yangchan Li; Min Gao; Li Han; Mark Wunderlich; Xiaolan Deng; Hongzhi Li; Yue Huang; Lei Gao; Chenying Li; Zhicong Zhao; Sean Robinson; Brandon Tan; Ying Qing; Xi Qin; Emily Prince; Jun Xie; Hanjun Qin; Wei Li; Chao Shen; Jie Sun; Prakash Kulkarni; Hengyou Weng; Huilin Huang; Zhenhua Chen; Bin Zhang; Xiwei Wu; Mark J. Olsen; Markus Müschen; Guido Marcucci; Ravi Salgia; Ling Li; Amir T. Fathi; Zejuan Li; James C. Mulloy; Minjie Wei; David Horne; Jianjun Chen

doi:10.1016/j.ccell.2020.04.017

Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion

Rui Su, Lei Dong, Yangchan Li, Min Gao, Li Han, Mark Wunderlich, Xiaolan Deng, Hongzhi Li, Yue Huang, Lei Gao, Chenying Li, Zhicong Zhao, Sean Robinson, Brandon Tan, Ying Qing, Xi Qin, Emily Prince, Jun Xie, Hanjun Qin, Wei LiChao Shen, Jie Sun, Prakash Kulkarni, Hengyou Weng, Huilin Huang, Zhenhua Chen, Bin Zhang, Xiwei Wu, Mark J. Olsen, Markus Müschen, Guido Marcucci, Ravi Salgia, Ling Li, Amir T. Fathi, Zejuan Li, James C. Mulloy, Minjie Wei, David Horne, Jianjun Chen

Research output: Contribution to journal › Article › peer-review

642 Scopus citations

Abstract

Su et al. develop two potent small-molecule inhibitors against an RNA N6-methyladenosine demethylase called FTO. FTO inhibition shows anti-tumor effects in several types of cancers in mouse models by restricting self-renewal of cancer stem cells and suppressing immune evasion.

Original language	English (US)
Pages (from-to)	79-96.e11
Journal	Cancer Cell
Volume	38
Issue number	1
DOIs	https://doi.org/10.1016/j.ccell.2020.04.017
State	Published - Jul 13 2020

Keywords

FTO
LILRB4
LSC/LIC self-renewal
N-methyladenosine (mA) modification
immune checkpoint genes
immune evasion
inhibitors
leukemia
solid tumors
therapeutics

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.ccell.2020.04.017

Cite this

Su, R, Dong, L, Li, Y, Gao, M, Han, L, Wunderlich, M, Deng, X, Li, H, Huang, Y, Gao, L, Li, C, Zhao, Z, Robinson, S, Tan, B, Qing, Y, Qin, X, Prince, E, Xie, J, Qin, H, Li, W, Shen, C, Sun, J, Kulkarni, P, Weng, H, Huang, H, Chen, Z, Zhang, B, Wu, X, Olsen, MJ, Müschen, M, Marcucci, G, Salgia, R, Li, L, Fathi, AT, Li, Z, Mulloy, JC, Wei, M, Horne, D & Chen, J 2020, 'Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion', Cancer Cell, vol. 38, no. 1, pp. 79-96.e11. https://doi.org/10.1016/j.ccell.2020.04.017

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title = "Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion",

abstract = "Su et al. develop two potent small-molecule inhibitors against an RNA N6-methyladenosine demethylase called FTO. FTO inhibition shows anti-tumor effects in several types of cancers in mouse models by restricting self-renewal of cancer stem cells and suppressing immune evasion.",

keywords = "FTO, LILRB4, LSC/LIC self-renewal, N-methyladenosine (mA) modification, immune checkpoint genes, immune evasion, inhibitors, leukemia, solid tumors, therapeutics",

author = "Rui Su and Lei Dong and Yangchan Li and Min Gao and Li Han and Mark Wunderlich and Xiaolan Deng and Hongzhi Li and Yue Huang and Lei Gao and Chenying Li and Zhicong Zhao and Sean Robinson and Brandon Tan and Ying Qing and Xi Qin and Emily Prince and Jun Xie and Hanjun Qin and Wei Li and Chao Shen and Jie Sun and Prakash Kulkarni and Hengyou Weng and Huilin Huang and Zhenhua Chen and Bin Zhang and Xiwei Wu and Olsen, \{Mark J.\} and Markus M{\"u}schen and Guido Marcucci and Ravi Salgia and Ling Li and Fathi, \{Amir T.\} and Zejuan Li and Mulloy, \{James C.\} and Minjie Wei and David Horne and Jianjun Chen",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = jul,

day = "13",

doi = "10.1016/j.ccell.2020.04.017",

language = "English (US)",

volume = "38",

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T1 - Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion

AU - Su, Rui

AU - Dong, Lei

AU - Li, Yangchan

AU - Gao, Min

AU - Han, Li

AU - Wunderlich, Mark

AU - Deng, Xiaolan

AU - Li, Hongzhi

AU - Huang, Yue

AU - Gao, Lei

AU - Li, Chenying

AU - Zhao, Zhicong

AU - Robinson, Sean

AU - Tan, Brandon

AU - Qing, Ying

AU - Qin, Xi

AU - Prince, Emily

AU - Xie, Jun

AU - Qin, Hanjun

AU - Li, Wei

AU - Shen, Chao

AU - Sun, Jie

AU - Kulkarni, Prakash

AU - Weng, Hengyou

AU - Huang, Huilin

AU - Chen, Zhenhua

AU - Zhang, Bin

AU - Wu, Xiwei

AU - Olsen, Mark J.

AU - Müschen, Markus

AU - Marcucci, Guido

AU - Salgia, Ravi

AU - Li, Ling

AU - Fathi, Amir T.

AU - Li, Zejuan

AU - Mulloy, James C.

AU - Wei, Minjie

AU - Horne, David

AU - Chen, Jianjun

PY - 2020/7/13

Y1 - 2020/7/13

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KW - FTO

KW - LILRB4

KW - LSC/LIC self-renewal

KW - N-methyladenosine (mA) modification

KW - immune checkpoint genes

KW - immune evasion

KW - inhibitors

KW - leukemia

KW - solid tumors

KW - therapeutics

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M3 - Article

C2 - 32531268

AN - SCOPUS:85086367037

SN - 1535-6108

VL - 38

SP - 79-96.e11

JO - Cancer Cell

JF - Cancer Cell

IS - 1

ER -

Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion

Abstract

Keywords

ASJC Scopus subject areas

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