Abstract
Su et al. develop two potent small-molecule inhibitors against an RNA N6-methyladenosine demethylase called FTO. FTO inhibition shows anti-tumor effects in several types of cancers in mouse models by restricting self-renewal of cancer stem cells and suppressing immune evasion.
Original language | English (US) |
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Pages (from-to) | 79-96.e11 |
Journal | Cancer Cell |
Volume | 38 |
Issue number | 1 |
DOIs | |
State | Published - Jul 13 2020 |
Keywords
- FTO
- LILRB4
- LSC/LIC self-renewal
- N-methyladenosine (mA) modification
- immune checkpoint genes
- immune evasion
- inhibitors
- leukemia
- solid tumors
- therapeutics
ASJC Scopus subject areas
- Oncology
- Cancer Research