Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion

Rui Su, Lei Dong, Yangchan Li, Min Gao, Li Han, Mark Wunderlich, Xiaolan Deng, Hongzhi Li, Yue Huang, Lei Gao, Chenying Li, Zhicong Zhao, Sean Robinson, Brandon Tan, Ying Qing, Xi Qin, Emily Prince, Jun Xie, Hanjun Qin, Wei LiChao Shen, Jie Sun, Prakash Kulkarni, Hengyou Weng, Huilin Huang, Zhenhua Chen, Bin Zhang, Xiwei Wu, Mark J. Olsen, Markus Müschen, Guido Marcucci, Ravi Salgia, Ling Li, Amir T. Fathi, Zejuan Li, James C. Mulloy, Minjie Wei, David Horne, Jianjun Chen

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

Su et al. develop two potent small-molecule inhibitors against an RNA N6-methyladenosine demethylase called FTO. FTO inhibition shows anti-tumor effects in several types of cancers in mouse models by restricting self-renewal of cancer stem cells and suppressing immune evasion.

Original languageEnglish (US)
Pages (from-to)79-96.e11
JournalCancer Cell
Volume38
Issue number1
DOIs
StatePublished - Jul 13 2020

Keywords

  • FTO
  • LILRB4
  • LSC/LIC self-renewal
  • N-methyladenosine (mA) modification
  • immune checkpoint genes
  • immune evasion
  • inhibitors
  • leukemia
  • solid tumors
  • therapeutics

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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