Targeting cell membrane adaptation as a novel antimicrobial strategy

Truc T. Tran, William R. Miller, Yousif Shamoo, Cesar A. Arias

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Emergence of antibiotic resistance is an example of the incredible plasticity of bacteria to survive in all environments. The search for new antibiotics active against traditional targets is more challenging due not only to the lack of novel natural products to fulfill the current clinical needs against multidrug-resistant (MDR) bacteria, but also for the possible ‘collateral’ effects on the human microbiota. Thus, non-traditional approaches to combat MDR bacteria have been proposed. Here, we discuss the possibility of targeting the membrane response to the antibiotic attack (cell membrane adaptation) as a viable strategy to increase the activity of current antimicrobials, enhance the activity of the innate immune system and prevent development of resistance during therapy using the three-component regulatory system LiaFSR of enterococci as a model.

Original languageEnglish (US)
Pages (from-to)91-96
Number of pages6
JournalCurrent Opinion in Microbiology
Volume33
DOIs
StatePublished - Oct 1 2016

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

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