Targeting Cancer Stemness in the Clinic: From Hype to Hope

Caner Saygin; Daniela Matei; Ravindra Majeti; Ofer Reizes; Justin D. Lathia

doi:10.1016/j.stem.2018.11.017

Targeting Cancer Stemness in the Clinic: From Hype to Hope

Caner Saygin, Daniela Matei, Ravindra Majeti, Ofer Reizes, Justin D. Lathia

Research output: Contribution to journal › Review article › peer-review

431 Scopus citations

Abstract

Saygin et al. discuss the clinical significance of cancer stem cells (CSCs) and results of potential CSC-targeting therapies in various cancers. They highlight barriers to translating cues from pre-clinical models into clinical applications and propose new strategies for rational design of future anti-CSC trials.

Original language	English (US)
Pages (from-to)	25-40
Number of pages	16
Journal	Cell Stem Cell
Volume	24
Issue number	1
DOIs	https://doi.org/10.1016/j.stem.2018.11.017
State	Published - Jan 3 2019

Keywords

cancer stem cell
CD123
differentiation therapies
hedgehog
niche
Notch

ASJC Scopus subject areas

Molecular Medicine
Genetics
Cell Biology

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10.1016/j.stem.2018.11.017

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title = "Targeting Cancer Stemness in the Clinic: From Hype to Hope",

abstract = "Saygin et al. discuss the clinical significance of cancer stem cells (CSCs) and results of potential CSC-targeting therapies in various cancers. They highlight barriers to translating cues from pre-clinical models into clinical applications and propose new strategies for rational design of future anti-CSC trials.",

keywords = "cancer stem cell, CD123, differentiation therapies, hedgehog, niche, Notch",

author = "Caner Saygin and Daniela Matei and Ravindra Majeti and Ofer Reizes and Lathia, \{Justin D.\}",

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year = "2019",

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AU - Matei, Daniela

AU - Majeti, Ravindra

AU - Reizes, Ofer

AU - Lathia, Justin D.

PY - 2019/1/3

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KW - CD123

KW - differentiation therapies

KW - hedgehog

KW - niche

KW - Notch

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Targeting Cancer Stemness in the Clinic: From Hype to Hope

Abstract

Keywords

ASJC Scopus subject areas

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