Targeted Maytansinoid Conjugate Improves Therapeutic Index for Metastatic Breast Cancer Cells

Zhengyang Jiang, Zhen Yang, Feng Li, Zheng Li, Nathan Fishkin, Kevin Burgess

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

This study was undertaken to target cell surface receptors other than the ones typically associated with breast cancer {estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2)}. It was also launched to use small molecules other than those most widely used for active targeting in general (e.g. folate and carbonic anhydrase IX ligands). Specifically, the focus of this study was on unique small molecules that bind the TrkC receptor, which is overexpressed in metastatic breast cancer. A conjugate (1) of a TrkC-targeting small molecule and the highly cytotoxic warhead, DM4 (a maytansinoid), was prepared. Cellular studies featuring TrkC+ and TrkC- human breast cells indicated this conjugate might have a better therapeutic effect than DM4 alone. It emerged that the conjugate 1 was very efficacious in vivo, completely ablating orthotopic 4T1 breast tumor in one case and dramatically reducing the tumor size in four other mice. Throughout, no significant weight loss or obvious neurotoxic effects were observed in the animals tested.

Original languageEnglish (US)
Pages (from-to)2920-2926
Number of pages7
JournalBioconjugate chemistry
Volume29
Issue number9
DOIs
StatePublished - Sep 19 2018

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Targeted Maytansinoid Conjugate Improves Therapeutic Index for Metastatic Breast Cancer Cells'. Together they form a unique fingerprint.

Cite this