Targeted Delivery of Shear Stress-Inducible Micrornas by Nanoparticles to Prevent Vulnerable Atherosclerotic Lesions

Wing Tak Wong, Shuangtao Ma, Xiao Yu Tian, Andrea Banuet Gonzalez, Eno E. Ebong, Haifa Shen

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Atherosclerosis is a chronic inflammatory vascular wall disease, and endothelial cell dysfunction plays an important role in its development and progression. Under the influence of laminar shear stress, however, the endothelium releases homeostatic factors such as nitric oxide and expresses of vasoprotective microRNAs that are resistant to atherosclerosis. Adhesion molecules such as E-selectin, exhibited on the endothelial surface, recruit monocytes that enter the vessel wall to form foam cells. Accumulation of these foam cells form fatty streaks that may progress to atherosclerotic plaques in the blood vessel wall. Interestingly, E-selectin may also serve as an affinity moiety for targeted drug delivery against atherosclerosis. We have recently developed an E-selectin-targeted platform that enriches therapeutic microRNAs in the inflamed endothelium to inhibit formation of vulnerable atherosclerotic plaques.

Original languageEnglish (US)
Pages (from-to)152-156
Number of pages5
JournalMethodist DeBakey cardiovascular journal
Volume12
Issue number3
DOIs
StatePublished - Sep 2016

Keywords

  • atherosclerosis
  • endothelial cell
  • microRNA
  • nanoparticle
  • vulnerable plaque

ASJC Scopus subject areas

  • Medicine(all)

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