Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis

Keyphrases

• Knock-in Mouse Model 100%
• Targeted Deletion 100%
• Cardiac Hypertrophy 100%
• Pressure Overload 100%
• Reactive Fibrosis 100%
• Profibrotic Cytokines 100%
• Myocardium 66%
• Cardiomyocytes 66%
• Ventricular Remodeling 66%
• Interstitial Fibrosis 33%
• Reduced Expression 33%
• Inhibitory Effect 33%
• Extracellular Matrix Protein 1 (ECM1) 33%
• Transgenic Mice 33%
• Overexpression 33%
• Compensatory Growth 33%
• Kinase Family 33%
• Pharmacological Inhibitors 33%
• Fibrosis 33%
• Aortic Banding 33%
• Gene Deletion 33%
• Cardiac Fibrosis 33%
• Ventricular Myocytes 33%
• Hypertrophic Response 33%
• Growth Response 33%
• Perivascular Fibrosis 33%
• Rho Kinase 33%
• Connective Tissue Growth Factor 33%
• Cardiac Induction 33%

Medicine and Dentistry

• Cytokine 100%
• Fibrosis 100%
• Fibrogenesis 100%
• Knockout Mouse 100%
• Myocardium 66%
• Cardiac Muscle Cell 66%
• Ventricular Hypertrophy 66%
• Heart Ventricle Remodeling 66%
• Cardiac Fibrosis 33%
• Scleroprotein 33%
• Transgenic Mouse 33%
• Idiopathic Pulmonary Fibrosis 33%
• Gene Deletion 33%
• Rho Kinase 33%
• Connective Tissue Growth Factor 33%

Biochemistry, Genetics and Molecular Biology

• ROCK1 100%
• Cytokine 33%
• Knockout Mouse 33%
• Fibrogenesis 33%
• Cardiac Muscle Cell 22%
• Extracellular Matrix Proteins 11%
• Scleroprotein 11%
• Phosphotransferase 11%
• Kinase 11%
• Transgenic Mouse 11%
• Gene Deletion 11%
• Connective Tissue Growth Factor 11%