Tailoring the degradation kinetics of mesoporous silicon structures through PEGylation

Biana Godin, Jianhua Gu, Rita E. Serda, Rohan Bhavane, Ennio Tasciotti, Ciro Chiappini, Xuewu Liu, Takemi Tanaka, Paolo Decuzzi, Mauro Ferrari

Research output: Contribution to journalArticle

122 Scopus citations

Abstract

Injectable and implantable porosified silicon (pSi) carriers and devices for prolonged and controlled delivery of biotherapeutics offer great promise for treatment of various chronic ailments and acute conditions. Polyethylene glycols (PEGs) are important surface modifiers currently used in clinic mostly to avoid uptake of particulates by reticulo-endothelial system (RES). In this work we show for the first time that covalent attachment of PEGs to the pSi surface can be used as a means to tune degradation kinetics of silicon structures. Seven PEGs with varying molecular weights (245, 333, 509, 686, 1214, 3400, and 5000 Da) were employed and the degradation of PEGylated pSi hemispherical microparticles in simulated physiological conditions was monitored by means of ICP-AES, SEM, and fluorimetry. Biocompatibility of the systems with human macrophages in vitro was also evaluated. The results clearly indicate that controlled PEGylation of silicon microparticles can offer a sensitive tool to finely tune their degradation kinetics and that the systems do not induce release of proinflammatory cytokines IL-6 and IL-8 in THP1 human macrophages.

Original languageEnglish (US)
Pages (from-to)1236-1243
Number of pages8
JournalJournal of Biomedical Materials Research - Part A
Volume94
Issue number4
DOIs
StatePublished - Sep 15 2010

Keywords

  • Biocompatibility
  • Biodegradation
  • Mesoporous silicon
  • Polyethylene glycol

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Ceramics and Composites
  • Metals and Alloys

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