T-cell therapy after hematopoietic stem cell transplantation

Alana A. Kennedy-Nasser, Malcolm Brenner

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

PURPOSE OF REVIEW: The separation of graft versus host disease from graft versus leukaemia reactivity and the reconstitution of immunity to infectious agents are the main goals of T-cell therapy after allogeneic hematopoietic stem cell transplantation. We describe how an improved understanding of T-cell mediated graft versus leukemia and of antiviral responses is providing effective approaches to T-cell immunotherapy. RECENT FINDINGS: Over the past several years, researchers have developed strategies to eliminate alloreactive T cells from the graft, to expand naturally occurring regulatory T cells, and to select and expand antigen-specific T cells specific for tumor-associated or viral antigens. Incorporation of suicide genes allows the selective destruction of allodepleted or antigen-selected cells after infusion, further increasing the safety and potential applicability of these approaches. SUMMARY: In this review we describe current strategies for adoptive T-cell immunotherapy after hematopoietic stem cell transplantation.

Original languageEnglish (US)
Pages (from-to)616-624
Number of pages9
JournalCurrent Opinion in Hematology
Volume14
Issue number6
DOIs
StatePublished - Nov 1 2007

Keywords

  • Cytotoxic T lymphocyte
  • Immunotherapy
  • Regulatory T cell
  • Suicide genes

ASJC Scopus subject areas

  • Hematology

Fingerprint

Dive into the research topics of 'T-cell therapy after hematopoietic stem cell transplantation'. Together they form a unique fingerprint.

Cite this