T cell therapies.

S. Gottschalk, C. M. Bollard, K. C. Straathof, C. U. Louis, B. Savoldo, G. Dotti, Malcolm Brenner, Helen Heslop, C. M. Rooney

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

T cell therapies are increasingly used for the treatment of malignancies and viral-associated diseases. Initial studies focused on the use of unmanipulated T cell populations after allogeneic stem cell transplantation. More recently, the use of antigen-specific T cells has been explored. This chapter reviews the clinical experience with polyclonal Epstein-Barr virus (EBV)-specific cytotoxic T cells (CTL) for the treatment of EBV-associated malignancies. Strategies on how to improve the antitumor activity of EBV-specific CTL are being discussed. If effective, these strategies will have broad implications for T cell therapies for a range of human tumors with defined antigens.

Original languageEnglish (US)
Pages (from-to)69-82
Number of pages14
JournalErnst Schering Foundation symposium proceedings
Volume4
StatePublished - 2006

ASJC Scopus subject areas

  • Medicine(all)

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