T-cell depletion of allogeneic bone marrow prevents acceleration of graft-versus-host disease induced by exogenous interleukin 2

Miroslav Malkovský, Malcolm K. Brenner, Ruth Hunt, Sohaila Rastan, Caroline Dore, Sheila Brown, Margaret E. North, Geoffrey L. Asherson, H. Grant Prentice, Peter B. Medawar

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Highly purified human recombinant interleukin 2 (IL-2) markedly accelerated lethal GVHD in the H-2-identical B10.BR → CBA combination, but had no effect when the donor cells were depleted of mature (Thy-1.2-positive) T lymphocytes, indicating a strong immunopotentiating effect of IL-2 on mature T cells causing GVHD. In the same donor-host combination, IL-2 did not influence the recovery from the post-transplantation bone marrow aplasia. The results suggest that IL-2 could be considered for adjuvant hormonal therapy to enhance immune recovery in recipients of T-cell-depleted allogeneic marrow.

Original languageEnglish (US)
Pages (from-to)476-480
Number of pages5
JournalCellular Immunology
Volume103
Issue number2
DOIs
StatePublished - Dec 1986

ASJC Scopus subject areas

  • Immunology

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