T-cell depletion of allogeneic bone marrow prevents acceleration of graft-versus-host disease induced by exogenous interleukin 2

Miroslav Malkovský; Malcolm K. Brenner; Ruth Hunt; Sohaila Rastan; Caroline Dore; Sheila Brown; Margaret E. North; Geoffrey L. Asherson; H. Grant Prentice; Peter B. Medawar

doi:10.1016/0008-8749(86)90108-5

T-cell depletion of allogeneic bone marrow prevents acceleration of graft-versus-host disease induced by exogenous interleukin 2

Miroslav Malkovský, Malcolm K. Brenner, Ruth Hunt, Sohaila Rastan, Caroline Dore, Sheila Brown, Margaret E. North, Geoffrey L. Asherson, H. Grant Prentice, Peter B. Medawar

Houston Methodist

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Highly purified human recombinant interleukin 2 (IL-2) markedly accelerated lethal GVHD in the H-2-identical B10.BR → CBA combination, but had no effect when the donor cells were depleted of mature (Thy-1.2-positive) T lymphocytes, indicating a strong immunopotentiating effect of IL-2 on mature T cells causing GVHD. In the same donor-host combination, IL-2 did not influence the recovery from the post-transplantation bone marrow aplasia. The results suggest that IL-2 could be considered for adjuvant hormonal therapy to enhance immune recovery in recipients of T-cell-depleted allogeneic marrow.

Original language	English (US)
Pages (from-to)	476-480
Number of pages	5
Journal	Cellular Immunology
Volume	103
Issue number	2
DOIs	https://doi.org/10.1016/0008-8749(86)90108-5
State	Published - Dec 1986

ASJC Scopus subject areas

Immunology

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title = "T-cell depletion of allogeneic bone marrow prevents acceleration of graft-versus-host disease induced by exogenous interleukin 2",

abstract = "Highly purified human recombinant interleukin 2 (IL-2) markedly accelerated lethal GVHD in the H-2-identical B10.BR → CBA combination, but had no effect when the donor cells were depleted of mature (Thy-1.2-positive) T lymphocytes, indicating a strong immunopotentiating effect of IL-2 on mature T cells causing GVHD. In the same donor-host combination, IL-2 did not influence the recovery from the post-transplantation bone marrow aplasia. The results suggest that IL-2 could be considered for adjuvant hormonal therapy to enhance immune recovery in recipients of T-cell-depleted allogeneic marrow.",

author = "Miroslav Malkovsk{\'y} and Brenner, {Malcolm K.} and Ruth Hunt and Sohaila Rastan and Caroline Dore and Sheila Brown and North, {Margaret E.} and Asherson, {Geoffrey L.} and Prentice, {H. Grant} and Medawar, {Peter B.}",

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T1 - T-cell depletion of allogeneic bone marrow prevents acceleration of graft-versus-host disease induced by exogenous interleukin 2

AU - Malkovský, Miroslav

AU - Brenner, Malcolm K.

AU - Hunt, Ruth

AU - Rastan, Sohaila

AU - Dore, Caroline

AU - Brown, Sheila

AU - North, Margaret E.

AU - Asherson, Geoffrey L.

AU - Prentice, H. Grant

AU - Medawar, Peter B.

PY - 1986/12

Y1 - 1986/12

N2 - Highly purified human recombinant interleukin 2 (IL-2) markedly accelerated lethal GVHD in the H-2-identical B10.BR → CBA combination, but had no effect when the donor cells were depleted of mature (Thy-1.2-positive) T lymphocytes, indicating a strong immunopotentiating effect of IL-2 on mature T cells causing GVHD. In the same donor-host combination, IL-2 did not influence the recovery from the post-transplantation bone marrow aplasia. The results suggest that IL-2 could be considered for adjuvant hormonal therapy to enhance immune recovery in recipients of T-cell-depleted allogeneic marrow.

AB - Highly purified human recombinant interleukin 2 (IL-2) markedly accelerated lethal GVHD in the H-2-identical B10.BR → CBA combination, but had no effect when the donor cells were depleted of mature (Thy-1.2-positive) T lymphocytes, indicating a strong immunopotentiating effect of IL-2 on mature T cells causing GVHD. In the same donor-host combination, IL-2 did not influence the recovery from the post-transplantation bone marrow aplasia. The results suggest that IL-2 could be considered for adjuvant hormonal therapy to enhance immune recovery in recipients of T-cell-depleted allogeneic marrow.

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T-cell depletion of allogeneic bone marrow prevents acceleration of graft-versus-host disease induced by exogenous interleukin 2

Abstract

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