Systemic Notch downregulation promotes KrasG12D-induced myeloproliferative neoplasm

Xiaona You; Zhi Wen; Yuan I. Chang; Erik A. Ranheim; Yun Zhou; Lan Zhou; Guangyao Kong; Jing Zhang

doi:10.1111/bjh.15893

Systemic Notch downregulation promotes Kras^G12D-induced myeloproliferative neoplasm

Xiaona You, Zhi Wen, Yuan I. Chang, Erik A. Ranheim, Yun Zhou, Lan Zhou, Guangyao Kong, Jing Zhang

Research output: Contribution to journal › Letter › peer-review

Original language	English (US)
Pages (from-to)	e52-e56
Journal	British Journal of Haematology
Volume	186
Issue number	3
DOIs	https://doi.org/10.1111/bjh.15893
State	Published - Aug 2019

Keywords

NOTCH signalling
myeloproliferative neoplasm
oncogenic Kras

ASJC Scopus subject areas

Hematology

Access to Document

10.1111/bjh.15893

Cite this

@article{d2e466c597b54896bc458056f9995fce,

title = "Systemic Notch downregulation promotes KrasG12D-induced myeloproliferative neoplasm",

keywords = "NOTCH signalling, myeloproliferative neoplasm, oncogenic Kras",

author = "Xiaona You and Zhi Wen and Chang, {Yuan I.} and Ranheim, {Erik A.} and Yun Zhou and Lan Zhou and Guangyao Kong and Jing Zhang",

note = "Funding Information: We are grateful to Patrick Nyman, Dr. Paul Lambert, and Dr. Warren Pear for providing the Rosa26LSL DNMAMl-GFP/+ mice and to Dr. Pamela Stanley for sharing the Pofut1fl/fl mice. We would like to thank the University of Wisconsin Carbone Comprehensive Cancer Center (UWCCC) for use of its Shared Services (Flow Cytometry Laboratory, Genome Editing and Animal Models Shared Resource, and Experimental Pathology Laboratory) to complete this research. This work was supported by the National Natural Science Foundation of China (NO.81600100) to G.K. and R01 grants CA152108 and HL113066 to J.Z. This work was also supported in part by NIH/NCI P30 CA014520–UW Comprehensive Cancer Center Support. Funding Information: We are grateful to Patrick Nyman, Dr. Paul Lambert, and Dr. Warren Pear for providing the Rosa26LSL DNMAML-GFP/+ mice and to Dr. Pamela Stanley for sharing the Pofut1fl/fl mice. We would like to thank the University of Wisconsin Carbone Comprehensive Cancer Center (UWCCC) for use of its Shared Services (Flow Cytometry Laboratory, Genome Editing and Animal Models Shared Resource, and Experimental Pathology Laboratory) to complete this research. This work was supported by the National Natural Science Foundation of China (NO.81600100) to G.K. and R01 grants CA152108 and HL113066 to J.Z. This work was also supported in part by NIH/NCI P30 CA014520–UW Comprehensive Cancer Center Support.",

year = "2019",

month = aug,

doi = "10.1111/bjh.15893",

language = "English (US)",

volume = "186",

pages = "e52--e56",

journal = "British Journal of Haematology",

issn = "0007-1048",

publisher = "Wiley",

number = "3",

}

TY - JOUR

T1 - Systemic Notch downregulation promotes KrasG12D-induced myeloproliferative neoplasm

AU - You, Xiaona

AU - Wen, Zhi

AU - Chang, Yuan I.

AU - Ranheim, Erik A.

AU - Zhou, Yun

AU - Zhou, Lan

AU - Kong, Guangyao

AU - Zhang, Jing

N1 - Funding Information: We are grateful to Patrick Nyman, Dr. Paul Lambert, and Dr. Warren Pear for providing the Rosa26LSL DNMAMl-GFP/+ mice and to Dr. Pamela Stanley for sharing the Pofut1fl/fl mice. We would like to thank the University of Wisconsin Carbone Comprehensive Cancer Center (UWCCC) for use of its Shared Services (Flow Cytometry Laboratory, Genome Editing and Animal Models Shared Resource, and Experimental Pathology Laboratory) to complete this research. This work was supported by the National Natural Science Foundation of China (NO.81600100) to G.K. and R01 grants CA152108 and HL113066 to J.Z. This work was also supported in part by NIH/NCI P30 CA014520–UW Comprehensive Cancer Center Support. Funding Information: We are grateful to Patrick Nyman, Dr. Paul Lambert, and Dr. Warren Pear for providing the Rosa26LSL DNMAML-GFP/+ mice and to Dr. Pamela Stanley for sharing the Pofut1fl/fl mice. We would like to thank the University of Wisconsin Carbone Comprehensive Cancer Center (UWCCC) for use of its Shared Services (Flow Cytometry Laboratory, Genome Editing and Animal Models Shared Resource, and Experimental Pathology Laboratory) to complete this research. This work was supported by the National Natural Science Foundation of China (NO.81600100) to G.K. and R01 grants CA152108 and HL113066 to J.Z. This work was also supported in part by NIH/NCI P30 CA014520–UW Comprehensive Cancer Center Support.

PY - 2019/8

Y1 - 2019/8

KW - NOTCH signalling

KW - myeloproliferative neoplasm

KW - oncogenic Kras

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DO - 10.1111/bjh.15893

M3 - Letter

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VL - 186

SP - e52-e56

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JF - British Journal of Haematology

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