@inbook{32c97a1334ee4c17b3676687dfa7f78b,
title = "Systemic modulation of lymphocyte subsets using siRNAs delivered via targeted lipid nanoparticles",
abstract = "Systemic delivery of RNA interference (RNAi) payloads for manipulation of gene expression in lymphocytes holds a great potential as a novel therapeutic modality for hematological malignancies and autoimmune disorders. However, lymphocytes are among the most difficult cells to transfect with RNAi, as they are resistant to conventional transfection reagents and are dispersed throughout the body, making it a challenge to successfully deliver these payloads via systemic administration route. We have developed a strategy to target lymphocytes and deliver RNAi payloads in a cell-specific manner to induce therapeutic gene silencing. This approach utilizes antibodies that decorate lipid nanoparticle surfaces to home into lymphocyte subsets. This approach opens new avenues for discovery of new drug targets and potentially for therapeutics.",
keywords = "Gene silencing, Lipid nanoparticles (LNPs), RNA interference (RNAi), Small interfering RNAs (siRNAs)",
author = "Inbal Hazan-Halevy and Daniel Rosenblum and Srinivas Ramishetti and Dan Peer",
note = "Funding Information: This work was supported in part by grants from the Dotan Hemato-oncology Center at Tel Aviv University, by the Lewis Trust for blood cancers and by the Leona M. and Harry B. Helmsley Nanotechnology Research Fund awarded to D.P. Publisher Copyright: {\textcopyright} Springer Science+Business Media, LLC, part of Springer Nature 2019. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",
year = "2019",
doi = "10.1007/978-1-4939-9220-1_11",
language = "English (US)",
series = "Methods in Molecular Biology",
publisher = "Humana Press",
pages = "151--159",
booktitle = "Methods in Molecular Biology",
}