Systemic inflammatory response syndrome

M. G. Davies, P. O. Hagen

Research output: Contribution to journalReview articlepeer-review

435 Scopus citations


Background: Localized inflammation is a physiological protective response which is generally tightly controlled by the body at the site of injury. Loss of this local control or an overly activated response results in an exaggerated systemic response which is clinically identified as systemic inflammatory response syndrome (SIRS). Compensatory mechanisms are initiated in concert with SIRS and outcome (resolution, multiple organ dysfunction syndrome or death) is dependent on the balance of SIRS and such compensatory mechanisms. No directed therapies have been successful to date in influencing outcome. Method: This review examines the current spectrum and pathophysiology of SIRS. Results and conclusion: Further clinical and basic scientific research is required to develop the global picture of SIRS, its associated family of syndromes and their natural histories.

Original languageEnglish (US)
Pages (from-to)920-935
Number of pages16
JournalBritish Journal of Surgery
Issue number7
StatePublished - 1997

ASJC Scopus subject areas

  • Surgery


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