Systemic immune modulation by stereotactic radiotherapy in early-stage lung cancer

Eleni Gkika; Elke Firat; Sonja Adebahr; Erika Graf; Ilinca Popp; Gianluca Radicioni; Simon S. Lo; Ursula Nestle; Nils H. Nicolay; Gabriele Niedermann; Dan G. Duda; Anca L. Grosu

doi:10.1038/s41698-023-00358-z

Systemic immune modulation by stereotactic radiotherapy in early-stage lung cancer

Eleni Gkika, Elke Firat, Sonja Adebahr, Erika Graf, Ilinca Popp, Gianluca Radicioni, Simon S. Lo, Ursula Nestle, Nils H. Nicolay, Gabriele Niedermann, Dan G. Duda, Anca L. Grosu

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

We performed a prospective study of circulating immune cell changes after stereotactic body radiotherapy (SBRT) in 50 early-stage NSCLC patients. We found no significant increase in CD8⁺ cytotoxic T lymphocytes at first follow-up (the primary endpoint) but detected a significant increase in expanding Ki-67⁺CD8⁺ and Ki-67⁺CD4⁺ T-cell fractions in patients treated with 10 Gy or less per fraction. SBRT can induce significant expansion in circulating effector T-cells immediately post-treatment.

Original language	English (US)
Article number	24
Journal	npj Precision Oncology
Volume	7
Issue number	1
DOIs	https://doi.org/10.1038/s41698-023-00358-z
State	Published - Dec 2023

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Systemic immune modulation by stereotactic radiotherapy in early-stage lung cancer",

abstract = "We performed a prospective study of circulating immune cell changes after stereotactic body radiotherapy (SBRT) in 50 early-stage NSCLC patients. We found no significant increase in CD8+ cytotoxic T lymphocytes at first follow-up (the primary endpoint) but detected a significant increase in expanding Ki-67+CD8+ and Ki-67+CD4+ T-cell fractions in patients treated with 10 Gy or less per fraction. SBRT can induce significant expansion in circulating effector T-cells immediately post-treatment.",

author = "Eleni Gkika and Elke Firat and Sonja Adebahr and Erika Graf and Ilinca Popp and Gianluca Radicioni and Lo, \{Simon S.\} and Ursula Nestle and Nicolay, \{Nils H.\} and Gabriele Niedermann and Duda, \{Dan G.\} and Grosu, \{Anca L.\}",

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year = "2023",

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doi = "10.1038/s41698-023-00358-z",

language = "English (US)",

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AU - Gkika, Eleni

AU - Firat, Elke

AU - Adebahr, Sonja

AU - Graf, Erika

AU - Popp, Ilinca

AU - Radicioni, Gianluca

AU - Lo, Simon S.

AU - Nestle, Ursula

AU - Nicolay, Nils H.

AU - Niedermann, Gabriele

AU - Duda, Dan G.

AU - Grosu, Anca L.

PY - 2023/12

Y1 - 2023/12

N2 - We performed a prospective study of circulating immune cell changes after stereotactic body radiotherapy (SBRT) in 50 early-stage NSCLC patients. We found no significant increase in CD8+ cytotoxic T lymphocytes at first follow-up (the primary endpoint) but detected a significant increase in expanding Ki-67+CD8+ and Ki-67+CD4+ T-cell fractions in patients treated with 10 Gy or less per fraction. SBRT can induce significant expansion in circulating effector T-cells immediately post-treatment.

AB - We performed a prospective study of circulating immune cell changes after stereotactic body radiotherapy (SBRT) in 50 early-stage NSCLC patients. We found no significant increase in CD8+ cytotoxic T lymphocytes at first follow-up (the primary endpoint) but detected a significant increase in expanding Ki-67+CD8+ and Ki-67+CD4+ T-cell fractions in patients treated with 10 Gy or less per fraction. SBRT can induce significant expansion in circulating effector T-cells immediately post-treatment.

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JO - npj Precision Oncology

JF - npj Precision Oncology

IS - 1

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ER -

Systemic immune modulation by stereotactic radiotherapy in early-stage lung cancer

Abstract

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