Systemic calciphylaxis revisited

H. J. Adrogue, M. R. Frazier, B. Zeluff, Wadi N. Suki

Research output: Contribution to journalArticlepeer-review

128 Scopus citations


A syndrome characterized by rapidly progressive ischemic necrosis involving large areas of the skin and muscle, and by peripheral gangrene associated with extensive vascular calcifications was observed in a patient with end-stage renal failure on chronic hemodialysis. In an effort to control the disease, parathyroidectomy was performed which resulted in rapid improvement of tissue perfusion. However, the patient eventually died from sepsis within 2 months after admission. This case presents the typical features of the syndrome of systemic, calciphylaxis. The literature is reviewed searching for similar cases of this poorly recognized, but life-threatening, clinical syndrome. The pathogenesis, clinical manifestations, and therapy of this unusual and rapidly progressive, but potentially reversible, condition are reviewed with emphasis on its prompt recognition and appropriate management.

Original languageEnglish (US)
Pages (from-to)177-183
Number of pages7
JournalAmerican Journal of Nephrology
Issue number3-4
StatePublished - 1981

ASJC Scopus subject areas

  • Nephrology


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