Synthetic biomineralisation yielding HA/collagen hybrid composite

A. Tampieri, M. Sandri, E. Landi, S. Sprio, F. Valentini, A. Boskey

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


The present work describes the development of biomimetic composite materials for bone tissue substitution and repair. Using a 'biologically inspired' synthesis, apatite/collagen (70:30 wt-%) biohybrid composites were developed, nucleating apatitic phases on self-assembling collagen, acting as a template. To reproduce the chemical composition of natural tissue, specific reactants were added during the synthesis process, to induce the growth of amorphous apatitic phases containing ions influent for the bone regeneration, namely,CO3 2-, Mg2+ and SiO4 4-, directly on the surface of the assembling organic fibrils. To increase the stability of the composite in physiological condition, a cross-linking agent was employed. The effect of natural proteins on the mineralisation process as well as the influence of the substituting ions on the crystallinity and morphology of the mineral particles was investigated. The features of the final composites were thoroughly examined in comparison with those of natural bone.

Original languageEnglish (US)
Pages (from-to)298-302
Number of pages5
JournalAdvances in Applied Ceramics
Issue number5
StatePublished - 2008


  • Biohybrid composites
  • Bone substitution
  • Collagen
  • Hydroxyapatite
  • Synthetic mineralisation

ASJC Scopus subject areas

  • Ceramics and Composites
  • Industrial and Manufacturing Engineering


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