TY - JOUR
T1 - Synthesis of the octa- and nonachlorobiphenyl isomers and congeners and their quantitation commercial polychlorinated biphenyls and identification in human breast milk
AU - Mullin, M.
AU - Sawka, G.
AU - Safe, L.
AU - McCrindle, S.
AU - Safe, S.
N1 - Funding Information:
The financial assistance of the United States Environmental Protection Agency (CR806928) is gratefully acknowledged. The human milk sample was made available by H. Price.
Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1981/5
Y1 - 1981/5
N2 - The synthesis of all possible isomeric nona- and octachlorobiphenyls has been accomplished by the Cadogan coupling of commercially available or synthetic chlorinated anilines in the presence of excess chlorinated benzenes and isoamyl nitrite. 2, 3, 4, 6-Tetrachloroaniline was prepared by the chlorination of 2, 4, 5-trichloroaniline. The synthetic polychlorinated biphenyls (PCBs) were characterized by their proton magnetic resonance and mass spectra and their purities determined by gas chromatographic analyses. The PCB standards were used to unambiguously identify the deca-, nona-, and octachlorobiphenyls present in human breast milk and in the commercial PCB preparations Aroclors 1268, 1262, 1260, 1254, 1248, 1242, 1016, 1232 and 1221 utilizing high resolution glass capillary gas chromatogrpahy.
AB - The synthesis of all possible isomeric nona- and octachlorobiphenyls has been accomplished by the Cadogan coupling of commercially available or synthetic chlorinated anilines in the presence of excess chlorinated benzenes and isoamyl nitrite. 2, 3, 4, 6-Tetrachloroaniline was prepared by the chlorination of 2, 4, 5-trichloroaniline. The synthetic polychlorinated biphenyls (PCBs) were characterized by their proton magnetic resonance and mass spectra and their purities determined by gas chromatographic analyses. The PCB standards were used to unambiguously identify the deca-, nona-, and octachlorobiphenyls present in human breast milk and in the commercial PCB preparations Aroclors 1268, 1262, 1260, 1254, 1248, 1242, 1016, 1232 and 1221 utilizing high resolution glass capillary gas chromatogrpahy.
UR - http://www.scopus.com/inward/record.url?scp=0019465144&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019465144&partnerID=8YFLogxK
U2 - 10.1093/jat/5.3.138
DO - 10.1093/jat/5.3.138
M3 - Article
C2 - 6790872
AN - SCOPUS:0019465144
VL - 5
SP - 138
EP - 142
JO - Journal of Analytical Toxicology
JF - Journal of Analytical Toxicology
SN - 0146-4760
IS - 3
ER -