Synthesis of the octa- and nonachlorobiphenyl isomers and congeners and their quantitation commercial polychlorinated biphenyls and identification in human breast milk

M. Mullin, G. Sawka, L. Safe, S. McCrindle, S. Safe

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

The synthesis of all possible isomeric nona- and octachlorobiphenyls has been accomplished by the Cadogan coupling of commercially available or synthetic chlorinated anilines in the presence of excess chlorinated benzenes and isoamyl nitrite. 2, 3, 4, 6-Tetrachloroaniline was prepared by the chlorination of 2, 4, 5-trichloroaniline. The synthetic polychlorinated biphenyls (PCBs) were characterized by their proton magnetic resonance and mass spectra and their purities determined by gas chromatographic analyses. The PCB standards were used to unambiguously identify the deca-, nona-, and octachlorobiphenyls present in human breast milk and in the commercial PCB preparations Aroclors 1268, 1262, 1260, 1254, 1248, 1242, 1016, 1232 and 1221 utilizing high resolution glass capillary gas chromatogrpahy.

Original languageEnglish (US)
Pages (from-to)138-142
Number of pages5
JournalJournal of Analytical Toxicology
Volume5
Issue number3
DOIs
StatePublished - May 1981

ASJC Scopus subject areas

  • Analytical Chemistry
  • Environmental Chemistry
  • Toxicology
  • Health, Toxicology and Mutagenesis
  • Chemical Health and Safety

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